Predictors of Pulmonary Hypertension in Patients With Advanced Lung Diseases
- Conditions
- Pulmonary Hypertension
- Registration Number
- NCT02777957
- Lead Sponsor
- Silesian Centre for Heart Diseases
- Brief Summary
First, the aim of the study was to evaluate the usefulness of echocardiographic parameters for detecting pulmonary hypertension (PH) in patients with advanced lung disease referred for lung transplantation. Second, to assess the prevalence of PH and to identify which hemodynamic, echocardiographic, pulmonary functional test, exercise capacity and biochemical parameters (especially NT-proBNP) have an impact on survival in a cohort of patients with severe lung diseases referred for lung transplantation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- advanced lung disease
- qualification for lung transplantation
- written informed consent
- pulmonary capillary wedge pressure < 15 mmHg
Exclusion Criteria
- cancer,
- history of idiopathic pulmonary hypertension,
- primary valvular heart diseases,
- coronary artery disease,
- collagen vascular disease,
- history or evidence of left ventricular dysfunction,
- atrial fibrillation,
- increased liver enzyme levels ( 3 times the upper laboratory limit),
- renal dysfunction (estimated glomerular filtration rate < 60 ml/min/1.73m2)
- patients who didn't write the personal informed consent
- any specific therapy for PH.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Survival after the initial right heart catheterization (RHC) measurements 1 year
- Secondary Outcome Measures
Name Time Method Survival to lung transplantation or the end of the observation period after the initial right heart catheterization (RHC) measurement 3 years
Trial Locations
- Locations (1)
Silesian Centre for Heart Diseases
🇵🇱Zabrze, Silesia, Poland