The repair of early tooth decay using a combination of stannous fluoride and a calcium milk peptide complex
Completed
- Conditions
- Dental caries (tooth decay)Oral HealthDental caries
- Registration Number
- ISRCTN10532332
- Lead Sponsor
- niversity of Melbourne
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 8
Inclusion Criteria
1. Eight healthy adults living in Melbourne, Australia with a fluoridated (0.9 ppm F), reticulated water supply
2. Staff and students of the University of Melbourne
3. Age 18-60 years
4. At least 22 natural teeth
5. Unstimulated whole salivary flow rate of = 0.2 ml/min
6. Gum-stimulated whole salivary flow rate = 1.0 ml/min
Exclusion Criteria
1. Currently using antibiotics or medications that may affect salivary flow rates
2. A history of severe oral disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effects of the rinses on enamel remineralization will be compared using integrated mineral gain/loss (?Zd-?Zr/%R) as the primary outcome measure. At the end of each treatment period each test half-slab will be paired with its control half-slab and embedded, sectioned and analysed by transverse microradiography to determine mineral content as described previously (Cochrane et al. 2012). Lesion parameters, lesion depth (LD) and integrated mineral loss (?Z) will be determined and the ?Z value for the control demineralized lesion will be designated ?Zd and that for the treated lesion will be designated ?Zr. These values will then be used to calculate total mineral loss or gain ?Zd-?Zr and percentage mineral change (%R) as (?Zd-?Zr/?Zd) x 100. The change in lesion depth will be calculated as LDd-LDr.
- Secondary Outcome Measures
Name Time Method The profile levels of fluoride and tin in enamel lesions remineralised measured using Electron Probe Microanalysis following exposure to the five solutions