The effect of probiotic supplementation on symptoms and quality of life of individuals suffering Allergic rhinitis

Phase 4

Completed

• Conditions: Allergic rhinitis; Inflammatory and Immune System - Allergies; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12615001103550
• Lead Sponsor: Griffith University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-10-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

For inclusion in the study participants are required to be aged between 17-60, have a history of moderate to severe persistent Allergic rhinitis, test positive to both a skin prick test and a radio-allergosorbent test to Bermuda (couch) grass.

Exclusion Criteria

Participants will be excluded from the study if they:
Suffer from non-allergic rhinitis;
Do not test positive for on the skin prick test and radio-allergosorbent test to Bermuda grass;
Have undergone treatment with systemic corticosteroids in the previous 6 months;
Have a history of respiratory or immune diseases;
Use of anti-inflammatory or immune modulating medications;
Consumption of probiotics or prebiotic supplements in the previous 12 weeks;
Use of Antibiotics within the last 30 days;
Are pregnant or intending to become pregnant during the trial period;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of life score associated with Allergic rhinitis. This will be assessed through completion and analysis of Rhinitis Quality of Life Questionnaires (RQLQ) and Allergic rhinitis symptoms on a Visual Analogue Scale and a composite score calculated. [Intervention period is 8 weeks. Primary endpoints will be determined before supplementation (week 0) and at the end of week 8. ]

Secondary Outcome Measures

Name	Time	Method
Change in degree of nasal congestion. This will be measured with through Nasal Rhinomanometry. [Endpoints will be determined before supplementation (week 0) and at the end of the supplementation period (week 8). ];Self-reported change in perceived resilience via the 10-item Connor Davidson Resilience Scale (CD-RISK). [Endpoints will be determined before supplementation (week 0) and at the end of the supplementation period (week 8)]