Explaining balance skill levels by cortical and spinal balance control mechanisms
Withdrawn
- Conditions
- Verouderingagingelderly
- Registration Number
- NL-OMON39653
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 94
Inclusion Criteria
Young group:
(1) Age 18 - 35 years ;Older group:
(1) Age 65 years or older
Exclusion Criteria
(1) Neurological disorders
(2) Not able to stand independently for 10 minutes without rest
(3) Pro-epileptogenic medications or medications known to affect balance
(4) Epilepsy
(5) Any metal in the brain/skull
(6) Pregnancy or suspicion of pregnancy (self-reported)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are the size of the short-interval intracortical<br /><br>inhibition (SICI), the amount of EMG suppression after subthreshold TMS and<br /><br>Hmax/Mmax ratio. SICI is the inhibition of the test motor evoked potential<br /><br>(MEP), when the suprathreshold TMS pulse (the test stimulus) is preceded by a<br /><br>few milliseconds with a subthreshold TMS pulse (the conditioning stimulus).<br /><br>SICI and EMG suppression are measures of motor cortical inhibition, and can<br /><br>thus be used to examine cortical influences. The Hmax/Mmax ratio, on the<br /><br>contrary, is a measure of the spinal influences.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameters is the Multiscale Entropy (MSE) complexity index<br /><br>of the CoP.</p><br>