Evolution of Maternal and Paternal-fetus Attachment in Egg Donation

Completed

• Conditions: Perinatal Disorder
• Interventions: Other: Questionnaires

• Registration Number: NCT05895175
• Lead Sponsor: Fundación IVI

Brief Summary

Recently, many families have been formed through gamete donation, a reproductive treatment where the ensuing children do not share a genetic link with either parents. However, despite such an increase, little is known about the parent-child relationship. Indeed, only two longitudinal studies have provided scientific background about family functioning in gamete donation. These studies showed that in egg donation families, the parent-child relationship was normal for parenting, parent psychological health, and child adjustment.

A more recent study evaluated mother-infant interaction in egg donation families comparing them with those created through IVF with their own gametes. Data collected showed that in egg donation families the mother-infant relationship quality appeared to be less optimal. Mothers were less interactive and stimulating, and infants showed lower involvement and less responsiveness with respect to their mothers Overall, the evidence suggests that women conceiving through egg donation likely require a variable period of adaptation to parenting. Here, the investigators aim to evaluate this interaction at an earlier stage, that is during the gestation. The specific bond that parents develop towards the fetus during pregnancy is called "parental-fetus attachment". Previous studies showed that the quality of the parental-fetus attachment is predictive of the quality of the postnatal parent-infant relationship and the child development The purpose is to evaluate whether the lack of genetic link with their offspring could undermine the parental attachment to the fetus, comparing couples conceiving through egg donation with those who get pregnant through a standard IVF treatment with their own gametes. No studies have been performed so far on this matter.

To assess the mother-father fetus attachment, the investigators will administer standardized and validated questionnaires to couples undergoing IVF with their own gametes, or egg donation cycles. For women, the investigators will use the Maternal Antenatal Attachment Scale . For men, the investigators will use the Paternal Antenatal Attachment Scale (PAAS-IT) . Furthermore, to also assess the emotional status of both partners, the investigators will use the Matthey Generic Mood Questionnaire .

Seeing that in the general population the maternal-fetal attachment level increases once women have completed the principal prenatal genetic screenings (like NIPT, CVS or amnio) and once they start perceiving the fetal movements, the investigators will administer the same questionnaire twice: between the 19-23 weeks and between the 28-32 weeks of gestation. This approach will enable monitoring of the evolution of the maternal and paternal fetal attachment at relevant gestational time-points.

As a result of the knowledge gathered from this study, the investigators will be able to develop a specific intervention strategy to promote this fundamental process for egg donation families.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-11-01
• Status Verified: 2023-05
• Study First Submitted: 2023-05-11
• Study First Submitted QC: 2023-06-06
• Study First Posted: 2023-06-08
• Primary Completion: 2024-03-30
• Study Completion: 2024-03-30
• Last Update Submitted: 2025-02-25
• Last Update Posted: 2025-02-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 132

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
DONATED GAMETE GROUP	Questionnaires	couples who got pregnant through egg donation (with their own semen)
OWN GAMETE GROUP	Questionnaires	couples who got pregnant through standard IVF treatment, with their own gametes

Primary Outcome Measures

Name	Time	Method
validated questionnaire to assess the change of maternal fetus attachment (MAAS)	between 19-23 gestational weeks and follow up between 28-32 weeks of gestation	The MAAS total score is calculated by the sum of all item of the questionnaire, and the subscales score (quality and intensity of the attachment) are calculated through the sum of the rate of each item that is included in that scale. Scoring is 1-5, with 5 high attachment
validated questionnaire to assess the change of Paternal fetus attachment (PAAS)	between 19-23 gestational weeks and follow up between 28-32 weeks of gestation	The PAAS total score is calculated by the sum of all item of the questionnaire, and the subscales score (quality and intensity of the attachment) are calculated through the sum of the rate of each item that is included in that scale. Scoring is 1-5, with 5 high attachment
questionnaire to explore the change of the Emotional status (Anxiety or depression feelings) during pregnancy (MGMQ)	between 19-23 gestational weeks and follow up between 28-32 weeks of gestation	The MGMQ provideds a screen positive / negative classification of emotional distress

Trial Locations

Locations (3)

IVI Roma; 🇮🇹 Roma, Italy

IVI Foundation; 🇪🇸 Valencia, Spain

IVI London; 🇬🇧 London, United Kingdom