Natriuretic Peptides as a Prognostic and Risk Stratification Tool in Assessment of Valvular Heart Disease

• Conditions: Valvular Heart Disease Stenosis and Regurgitation

• Registration Number: NCT05439369
• Lead Sponsor: Assiut University

Brief Summary

NPs can be used To detect subset of asymptomatic with subtle LV dysfunction for further evaluation and earlier referral for intervention and its correlation with echocardiographic finding.

Detailed Description

Each patient included in the study will undergo:

1. History taking:

Analysis of patient symptoms and signs (dyspnea , orthopnea , Paroxysmal nocturnal dyspnea, lower limb edema , tachypalpitations,...etc )

2. Clinical examination:

* Detecion of each patient body weight , height , calculation of BMI.

* General examination for detection of signs of Heart failure (raised JVP , lower limb edema, ..etc)

* Examination to respiratory system

* Auscultation of the heart for detection of valvular affection before echocardiography

Invesigations:

Laboratory investigations:

Urea and creatinine . b) ECG : for exclusion of atrial fibrillation and other arrythmias. 2D Transthorathic Echocardiography (TTE) Evaluation of valve morphology and thickness , gradients and valve area , regurgitant lesions and its severity.

Evaluation of internal cardiac dimensions and function. 5- Natriuretic peptides: as a useful screening tool to differentiate symptomatic and asymptomatic patients.

Study Timeline

• Status Verified: 2022-06
• Study First Submitted: 2022-06-17
• Study First Submitted QC: 2022-06-29
• Last Update Submitted: 2022-06-29
• Study First Posted: 2022-06-30
• Last Update Posted: 2022-06-30
• Study Start: 2022-08-01
• Primary Completion: 2023-01-01
• Study Completion: 2023-01-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• All patients echocardiographically diagnosed with significant valve lesions. Rheumatic Heart disease with significant but asymptomatic valvular Heart Disease especially (Mitral valve disease )(MS and MR) Gender: male & female

Exclusion Criteria

• Cases with increased level of BNP as in :

Renal impairment Advanced age and obesity Atrial fibrillation and acute coronary syndromes Prior lung diseases and acute illness

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
early detection of subclinical LV dysfunction.	1 year	early detection of subclinical LV dysfunction.

Trial Locations

Locations (1)

Assiut University ,faculty of medicine; 🇪🇬 Assiut, Egypt