EKOS in Patients With Pulmonary Embolism (PE)

Completed

• Conditions: Pulmonary Embolism
• Interventions: Drug: ECOS; Drug: Control group

• Registration Number: NCT06738108
• Lead Sponsor: Beni-Suef University

Brief Summary

A retrospective cohort study assessed patients who underwent EKOS intervention following the failure of initial therapeutic anticoagulation for managing acute pulmonary embolism at a tertiary hospital.

Detailed Description

A retrospective cohort study assessed patients who underwent EKOS intervention following the failure of initial therapeutic anticoagulation for managing acute pulmonary embolism at a tertiary hospital. Patients aged at least 18 years with a diagnosis of submassive or massive acute PE were included. Patients were excluded if they either did not receive EKOS intervention or were presented with stable PE. The primary outcome was the change in RV/LV diameter ratio from baseline to first outpatient follow-up.

Study Timeline

• Study Start: 2024-12-13
• Study First Submitted: 2024-12-13
• Study First Submitted QC: 2024-12-13
• Study First Posted: 2024-12-17
• Primary Completion: 2024-12-20
• Status Verified: 2025-01
• Study Completion: 2025-01-08
• Last Update Submitted: 2025-01-08
• Last Update Posted: 2025-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

• Patients ≥ 18 years diagnosed with massive or submassive acute PE.

Exclusion Criteria

1. Patients presented with stable PE
2. Patients did not receive EKOS intervention.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ECOS group	ECOS	ECOS
Control group	Control group	IV infusion tpa

Primary Outcome Measures

Name	Time	Method
The change in RV/LV diameter ratio	one month	The change in RV/LV diameter ratio from baseline to first outpatient follow-up as documented on an echocardiogram.

Secondary Outcome Measures

Name	Time	Method
All-cause 30-day readmission	one month	All-cause 30-day readmission

Trial Locations

Locations (1)

Saudi German Hospital; 🇪🇬 Cairo, Egypt