Prevalence and Care Partner Burden of Individuals With Alzheimer's Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer Disease
- Sponsor
- Vanderbilt University Medical Center
- Enrollment
- 240
- Locations
- 1
- Primary Endpoint
- Swallowing safety
- Status
- Recruiting
- Last Updated
- 10 months ago
Overview
Brief Summary
This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throughout the disease course in people with AD. The overall objective of this study is to evaluate swallowing function in adults with and without Alzheimer's disease. The investigator will also be involving the primary caregivers of individuals with Alzheimer's that are enrolled in the study to better understand the impact of swallowing impairments on the primary caregivers of those with Alzheimer's Disease.
Healthy adults and individuals with Alzheimer's disease will:
- undergo tests of cough and swallow function
- undergo tests of grip and tongue strength
- complete questionnaires
Caregivers of individuals with Alzheimer's disease will also complete questionnaires.
Detailed Description
This study will involve one in-person research visit that will last approximately 1-1.5 hours and will consist of a screening, cough testing, swallow function testing, assessments of hand grip and tongue strength, and completion of questionnaires. Caregivers of those with Alzheimer's disease will also complete questionnaires.
Investigators
Cara Donohue, Ph.D. CCC-SLP
Assistant Professor, Director of Medical Speech-Language Pathology
Vanderbilt University Medical Center
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Swallowing safety
Time Frame: During baseline visit at time of enrollment.
The penetration aspiration scale is a validated 8-point ordinal rating scale that measures the depth of airway invasion and the patient's response during swallowing. Scores range from 1 to 8 with a score of 1 indicating a safe swallow (best score) and 8 indicating silent aspiration (worst score).
Secondary Outcomes
- Voluntary cough peak expiratory flow(During baseline visit at time of enrollment)
- Grip strength(During baseline visit at time of enrollment.)
- Tongue strength(During baseline visit at time of enrollment.)
- Swallowing and Eating Related Fatigue Questionnaire (SERF)(During baseline visit at time of enrollment.)
- Swallowing Related Quality of Life Questionnaire (SWAL-QOL)(During baseline visit at time of enrollment.)
- Eating Assessment Tool 10 (EAT-10)(During baseline visit at time of enrollment.)
- Caregiver Analysis of Reported Experiences with Swallowing Disorders (CARES) Questionnaire(During baseline visit at time of enrollment.)
- Caregiver Self-Assessment Questionnaire(During baseline visit at time of enrollment.)
- 3 oz water swallow test(During baseline visit at time of enrollment.)
- Reflex cough(During baseline visit at time of enrollment.)
- Screening for Oral Frailty Tool (SOFT)(During baseline visit at time of enrollment.)