EFFECT OF INTRAARTICULAR TRIAMCINOLONE HEXACETONIDE AND BETAMETHASONE ON INTRAOCULAR PRESSURE

Not Applicable

Completed

• Conditions: Knee Osteoarthritis (Knee OA); Intraocular Pressure
• Interventions: Drug: Diprospan; Drug: artropan

• Registration Number: NCT07242846
• Lead Sponsor: Nigde Omer Halisdemir University

Brief Summary

This study is being done to find out whether two commonly used corticosteroid injections for knee osteoarthritis - betamethasone and triamcinolone hexacetonide - have different effects on eye pressure (intraocular pressure). Adults with painful early-stage knee osteoarthritis who have not improved with standard treatments receive one of these injections into the knee joint as part of their usual care. Eye pressure in both eyes is measured before the injection and one week later. By comparing the change in eye pressure between the two steroid groups, the study aims to better understand the risk of steroid-related increases in eye pressure and to help doctors choose safer treatment options, especially for patients who may be at risk for glaucom

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-10
• Study Start: 2025-10-02
• Primary Completion: 2025-11-02
• Study Completion: 2025-11-10
• Study First Submitted: 2025-11-17
• Study First Submitted QC: 2025-11-17
• Last Update Submitted: 2025-11-17
• Study First Posted: 2025-11-21
• Last Update Posted: 2025-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Symptomatic early-stage knee osteoarthritis Patients aged 18-75 years No prior eye surgery No history of elevated IOP or glaucoma diagnosis Patients not receiving any medical treatment altering IOP

Exclusion Criteria

• IOP >21 mm Hg Patients with a previous or current diagnosis of glaucoma Patients aged <18 and >75 years History of or ongoing ocular disease Use of medications (oral CSs, diazoxide, etc.) altering IOP

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Betamethasone	Diprospan	Intraarticular betamethasone group
Triamcinolone Hexacetonide	artropan	Intraarticular triamcinolone hexacetonide

Primary Outcome Measures

Name	Time	Method
Change in Intraocular Pressure (IOP) From Baseline to 1 Week	Baseline (before intra-articular steroid injection) and 1 week after injection	ntraocular pressure (IOP) in both eyes will be measured in mmHg using noncontact tonometry at baseline (before the intra-articular injection) and 1 week after the injection. Change in IOP (ΔIOP) will be calculated for each eye as the value at 1 week minus the baseline value. The primary outcome is the mean change in IOP in each treatment group

Trial Locations

Locations (1)

Niğde Ömer Halisdemir University; Niğde, Turkey (Türkiye)