NCT01127945
Completed
N/A
A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Evaluate the Effectiveness of High Dose Statin Loading in Acute Heart Failure Patients
ConditionsAcute Heart Failure
Interventionsstatin
Overview
- Phase
- N/A
- Intervention
- statin
- Conditions
- Acute Heart Failure
- Sponsor
- Yonsei University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- hsCRP levels
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
This is a prospective, single-center, randomized, controlled, open-label, pilot study to evaluate the effectiveness of high dose statin loading in acute heart failure patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Dyspnea at rest or minimal activity
- •Tachypnea (respiratory rate \> 20/min) or rales or pulmonary edema on chest X-ray
Exclusion Criteria
- •Acute coronary Syndrome
- •Hospitalization plan for PTCA or CABG
- •Cardiogenic shock (Systolic Blood Pressure \< 80mmHg)
- •Uncontrolled hypertension (Systolic Blood Pressure \> 180mmHg)
- •Allergy, adverse drug reaction, hypersensitivity to statin
- •Troponin \> 5 times upper limit of normal (ULN)
- •Creatinine kinase-MB level \> 3 times ULN
- •AST, ALT \> 3 times ULN or acute hepatitis
- •Current or past history of muscle disease, rhabdomyolysis
- •Life expectancy \< 6 months (e.g. metastatic malignancy, liver cirrhosis)
Arms & Interventions
atorvastatin 80mg
Intervention: statin
conventional therapy (for heart failure)
Intervention: statin
Outcomes
Primary Outcomes
hsCRP levels
Time Frame: at hospital day #4
to investigate the effect of high dose statin loading on the change of serum NT-proBNP, hsCRP levels in patients with acute heart failure
Study Sites (1)
Loading locations...
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