Randomized Control Trial to compare Carbetocin and Oxytocin in the prevention of Postpartum Hemorrhage (PPH) in Elective Caesarean Section
试验速览
- 阶段
- 2 期
- 状态
- Not Applicable
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Carbetocin is better compared to Oxytocin in prevention of Post partum haemorrhage
研究概览
简要总结
Postpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality worldwide, accounting for around one-fourth of all maternal deaths. Elective Caesarean Section (ECS) is a known risk factor for PPH, with an incidence of PPH ranging from 3.3% to 6.5%. Oxytocin is the current standard of care for the prevention of PPH during ECS, with certain limitations, such as need for refrigeration and short half-life. Carbetocin is a newer uterotonic drug that has shown to be as effective as oxytocin in the prevention of PPH, with the added advantage of longer half-life and no need of refrigeration. However, there is a lack of data on the comparative effectiveness of Carbetocin and Oxytocin in preventing PPH during ECS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •all willing pts term pregnancies undergoing elective lscs.
排除标准
- •all unwilling pts, emergency LSCS,pts with cardiac disease,renal disease,liver disease, epilepsy.
结局指标
主要结局
Carbetocin is better compared to Oxytocin in prevention of Post partum haemorrhage
时间窗: till 48 hours post surgery
次要结局
- Carbetocin is similar to Oxytocin in prevention of post partum haemorrhage(till 48 hours post surgery)
研究者
Sandyarani Dodamani
INHS Asvini