Dexamethasone in community-acquired pneumonia. - Santeon-CAP study

Sint Antonius Ziekenhuis0 个研究点目标入组 600 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Patients aged 18 to 100 years with a community-acquired pneumonia which requires admission.
•Criteria to determine a community-acquired pneumonia:
•- Chest radiograph showing new opacities.
•In combination with two of the following findings:
•0 Production of sputum
•0 Temp >38,0 °C or <36,0 °C
•0 Audible abnormalities by chest examination compatible with pneumonia
•0 Leukocytosis (>10.000 cells/mm3), leftward shift (>10%) or leucopenia (<4000 cells/mm3)
•0 CRP >15 mg/l (three fold higher than the upper limit of normal)

•- Immunocompromised patients:
•0 Patients with a known congenital or acquired immunodeficiency.
•0 Patients who received chemotherapy less than 6 weeks ago.
•0 Patients who received corticosteroids in the last 6 weeks.
•0 Patients who received immunosuppressive medication in the last 6 weeks (e.g. cyclosporin, cyclophosphamide, azathioprine).
•0 Patients with COPD who are on systemic corticosteroids for COPD.
•- Patients who require ICU treatment.
•- Patients with tropical worm infection.
•- Patients with dexamethasone intolerance.
•- Pregnant and breastfeeding women.

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