Pronostic Value of Endothelial Dysfunction in Heart Failure

Terminated

• Conditions: Heart Decompensation; Cardiac Failure

• Registration Number: NCT02859636
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

The main objective is to evaluate the pronostic value of endothelial dysfonction in acute heart failure on a combined criteria associating cardiovascular mortality, nex hospitalisation for decompensated heart failure, cardiac graft or ventricular assistance 2 month and 1 year before acute heart failure.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Primary Completion: 2016-03
• Study Completion: 2016-03
• Status Verified: 2016-08
• Study First Submitted: 2016-08-02
• Study First Submitted QC: 2016-08-04
• Last Update Submitted: 2016-08-04
• Study First Posted: 2016-08-09
• Last Update Posted: 2016-08-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• patients hospitalized for acute heart fialure with Left Ventricular Ejection Fraction (LVEF) < 45 % on echocardiography

Exclusion Criteria

• Informed consent form not signed
• Cardiogenic, septic or hemorragic shock
• Acute coronary syndrom with elevated troponin
• valvular surgery or aorto-coronary graft during next 3 months
• Cancer
• Pregnancy
• life expectancy over than 1 year
• chronic renal impairment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
hospitalisation	6 months
catecholamins	6 months
late endothelial progenitors	6 months
mortality	6 months
MR Proadrenomedulline	6 months
Peripheral tissular perfusion	6 months	Near infra-red spectroscopy