Effects of MDMA on Responses to Affective Touch in Individuals With a Range of Autistic Traits
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Change in Responses to Affective Touch
研究概览
简要总结
To study the effects of a psychostimulant on responses to affective touch in individuals with a range of autistic traits
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI between 19 and 30 (no one under 130 lbs)
- •Smokers smoking less than 25 cigarettes per week
- •Have used ecstasy no more than 40 times with no adverse responses.
排除标准
- •High blood pressure
- •Any medical condition requiring regular medication
- •Individuals with a current (within the last year) DSM-IV Axis 1 diagnosis
- •Individuals with a history of dependence on stimulant drugs.
- •Women who are pregnant or trying to become pregnant
研究组 & 干预措施
Placebo Then MDMA
Participants first receive placebo at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive MDMA (1.5 mg/kg)
干预措施: MDMA (Drug)
Placebo Then MDMA
Participants first receive placebo at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive MDMA (1.5 mg/kg)
干预措施: Placebo oral tablet (Drug)
MDMA Then Placebo
Participants first receive MDMA (1.5 mg/kg) at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive placebo.
干预措施: MDMA (Drug)
MDMA Then Placebo
Participants first receive MDMA (1.5 mg/kg) at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive placebo.
干预措施: Placebo oral tablet (Drug)
结局指标
主要结局
Change in Responses to Affective Touch
时间窗: 1.5 hrs after drug or placebo administration.
Participants will complete an affective touch task during which time they will rate pleasantness of touch on a scale of -10 to +10 using an analog scale. Higher ratings indicate greater pleasantness.
次要结局
未报告次要终点