The effect of radiation therapy of the prostate on parameters, which can be acquired by magnetic resonance tomography: relaxation times, apparent diffusion coefficient and perfusion.
- Conditions
- C61Malignant neoplasm of prostate
- Registration Number
- DRKS00002954
- Lead Sponsor
- niversitätsklinikum Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 6
Male patients older than 18 years, with histologically confirmed prostate cancer.
- Where the biopsy at the time of the first MR examination at least 6 weeks is back
- The radiation therapy can be obtained as primary therapy (5 x 2 Gy / week up to a total dose of 72-76 Gy)
- Have no restriction on the kidney function.
- No contraindications for the whole-body MRI
- Consent to participate in the study after detailed explanation of previous and written consent
- TURP prior to study inclusion
- Pre-irradiation in the pelvic area
- Start an anti-hormonal therapy prior to study entry
- Contraindications to MR studies (pacemakers, metallic clips after magnetizable brain or heart surgery, cochlear implants, metallic foreign body in the eye, insulin pumps, etc.).
- Ferromagnetic intracorporeal debris
- SM / AICD implantation
- Lack of written informed consent
- Combined radiation therapy (HDR afterloading percutaneous)
- Severe allergic diathesis
- Known allergy to contrast agent gadolinium-chelates
- Renal (filtration rate <40 ml / min)
- prior kidney and liver transplant
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Based on MRI to quantitative parameters (relaxation times, Apparent diffusion coefficient and perfusion) are determined before and after radiotherapy of prostate cancer.
- Secondary Outcome Measures
Name Time Method A correlation between changes in MRI parameters and the PSA level can be checked further.