PBMC-therapy and treatment of recurrent implantation failure (RIF)
Phase 1
- Conditions
- Recurrent implantation failure.Complication associated with artificial fertilization, unspecifiedN98.9
- Registration Number
- IRCT2017081227520N8
- Lead Sponsor
- Stem Cell And Regenerative Medicine Institute,Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 100
Inclusion Criteria
Having at least three implantation failures after IVF
Having primary infertility
Age under 45 years old
Having regular menstrual cycles
BMI under 30
Exclusion Criteria
Having polycystic ovarian syndrome
The presence of uterine pathology;
Poor ovarian reserve
Having chromosomal abnormalities
Presence of auto anti-bodies such as anti-TPO, anti-TG, ACA, APA, ANA, and anti-dsDNA
Presence of mutations involving the coagulation system such as deficiency of factor XII, Pro C, Pro S
Positive HIV, HCV or HBV tests
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pregnancy rate. Timepoint: After positive beta-hCG test, clinical pregnancy was evaluated at 5-6 week. Method of measurement: Laboratory tests and ultrasound.
- Secondary Outcome Measures
Name Time Method