Efficacy and safety of wrist ankle acupuncture combined with oxycodone hydrochloride in the treatment of hepatocellular carcinoma with moderate and severe cancer pain: A protocol of a randomized, single-blind, placebo-controlled clinical trial
Phase 1
- Conditions
- hepatocellular carcinomacancer painCancer pain is one of the most principal clinical symptoms in patients with advanced hepatocellular carcinoma (HCC), which seriously affects the quality of life of patients. How to effectively control cancer pain and reduce adverse drug reactions is the focus of clinical research. Wrist-ankle acupuncture (WAA) is reliable in the treatment of cancer pain, but there are few high-quality and effective follow-up clinical studies on WAA in the treatment of moderate and severe cancer pain in HCC.wrist-ankle acupuncturerandomized controlled trialprotocol
- Registration Number
- TCTR20220427002
- Lead Sponsor
- Zhilin Zhou
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
1 .Patients who are in accordance with the diagnosis of HCC .
2. Aged: 18 to 75 years old, stable and conscious.
3. Patients who have moderate and severe pain, and the 11-point numerical rating scale
4. Patients whose expected survival is over 6 months.
(5). Patients who have strong compliance and have signed informed consent.
Exclusion Criteria
1. Patients who are accompanied by infectious diseases, diseases of blood system
2. Patients who have history of acupuncture syncope
3. Women in pregnancy or lactation
4. Patients who have pain associated with causes other than HCC
5. Complicated with other acute symptoms.
6. Skin ulceration at the needling site.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 11-point numerical rating scale (NRS) 7 days Pain will be measured from 0 to 10, with 0 being no pain and 10 being severe pain.
- Secondary Outcome Measures
Name Time Method Effective rate 7 days effective rate complete response number partial response number effective number total number