Effect of SSRI and SNRI on various mental activities including learning and problem solving among patients suffering from major depressive disorder

Recruiting

Conditions: All adult diagnosed patients of MDD as per ICD 10 criteria in remission phase

Registration Number: CTRI/2018/06/014537

Lead Sponsor: Department of Pharmacology IPGMER

Brief Summary: The primary purpose of the study is to study the effects of SSRI and SNRI on various domains of cognitive functions in patients with Major Depressive Illness. The secondary purpose of the study is to asses the nature of cognitive function changes due to use of drugs of interest.

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 50

Inclusion Criteria

1)Adult patients (18 years to 50 years) of either gender attending psychiatry OPD at IOP, with a clinical diagnosis of Major Depressive Disorder as per ICD10 criteria. 2)Subjects of MDD must be in remission phase with a Hamilton Depressive Rating Score (HAM-D 17) of <7) at enrolment and taking any of the following SSRIs.
fluoxetine, sertraline, escitalopram and/or SNRI like mirtazapine for at least last 6 months. Patients who are additionally on cognitive behavioral therapy (CBT) as part of their treatment shall also be included. 3)Subjects should have at least 8 years of formal school education in order to undertake the cognitive function tests. 4)Subjects or their care givers should be willing to give written informed.

Exclusion Criteria

1)History of post traumatic or Obsessive compulsive Disorder (OCD) 2)History of schizophrenia, psychosis or bipolar delusional disorder 3)History of intake of any drugs that are likely to have effect on cognition (anticonvulsants, sedative hypnotics, neuroleptics, opioids) 4)History of addictions- alcohol, substance abuse.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in cognitive function score	Attime points- 3, 6 and 9 months from the date of commencement of study.Both the absolute changes and percentage change from enrollment visit to 9 months visit shall be computed.

Secondary Outcome Measures

Name	Time	Method
the nature of the changes in different domains of cognitive functions and to analyze whether there are any observable differences in the effects of the individual drugs on cognitive function.	At time points- 3, 6 and 9 months from the date of commencement of study.

Trial Locations

Locations (1): Institute Of Psychiatry
🇮🇳
Kolkata, WEST BENGAL, India
Institute Of Psychiatry
🇮🇳Kolkata, WEST BENGAL, India
Dr Sayanta Thakur
Principal investigator
8017032224
tsayanta83@gmail.com