Effect of dipeptidyl peptidase 4 inhibitors on Glomerulotubular regulation of sodium balance and circadian blood pressure rhythm.
Not Applicable
Recruiting
- Conditions
- Type 2 diabetic nephrology
- Registration Number
- JPRN-UMIN000024426
- Lead Sponsor
- agoya City University Graduate School of Medical Sciences Department of Cardio-Renal Medicine and Hypertension
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1) GFR <30 30ml/min/1.73m2 or undergoing renal replacement therapy 2) severe ketosis, diabetic coma or pre-come 3) conditions with serious infection, perioperative period, and severe trauma 4) presence/possibility for pregnancy/lactation 5) GOT >100, or GPT >85 6) current treatment with insulin 7) any reason for ineligibility suggested by the attending doctor (history of allergic reaction to study medication)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decrease in night/day ratio of blood pressure during 8 week treatment with DPP4 inhibitors (week 8)
- Secondary Outcome Measures
Name Time Method 1) increase in daytime urinary sodium excretion (day2) 2) decrease in glomerulotubular Na balance (SNa x GFR, tNa) 3) constancy of daily urinary Na excretion 4) sympathetic and parasympathetic nerve activity (assessed by heart rate variability) 5) HbA1c 6) urine anion gap, serum bicarbonate concentration