Strontium Ranelate and KOA
- Conditions
- Knee Osteoarthritis
- Interventions
- Other: physiotherapy
- Registration Number
- NCT03937518
- Lead Sponsor
- Mansoura University
- Brief Summary
The present study was carried out on thirty patients with primary knee osteoarthritis. Patients were recruited from Rheumatology and Rehabilitation
Outpatient Clinic at Mansoura University Hospi Patients were divided into two groups:
Group 1: included 15 patients who received oral strontium ranelate and physiotherapy program. The age of the patients ranged from 50 to 62 years, they were 11 females and 4 males. Group 2: included 15 patients who received physiotherapy program. The age of the patients ranged from 50 to 62 years, they were 12 females and 3 males. Written consent was obtained from each participant sharing in the study. This study was approved by the institution research board of faculty of medicine, Mansoura University, code: MS/15.10.08. Inclusion
- Detailed Description
The present study was carried out on thirty patients with primary knee osteoarthritis. Patients were recruited from Rheumatology and Rehabilitation
Outpatient Clinic at Mansoura University Hospi Patients were divided into two groups:
Group 1: included 15 patients who received oral strontium ranelate and physiotherapy program. The age of the patients ranged from 50 to 62 years, they were 11 females and 4 males. Group 2: included 15 patients who received physiotherapy program. The age of the patients ranged from 50 to 62 years, they were 12 females and 3 males. Written consent was obtained from each participant sharing in the study. This study was approved by the institution research board of faculty of medicine, Mansoura University, code: MS/15.10.08.
InclusionAll patients were subjected to the following:
I. History Taking :
1. Personal History
* Name, age, sex, residence, marital status.
* Occupational status.
* Special habits e.g. smoking status (current/previous).
2. Complaint:
Taken in the patient's own words with special stress on disease duration.
3. Present history:
Onset, course and duration of disease. Analysis of complaint Pain: type of pain, site of pain, factors participating/alleviating pain. Swelling. Crepitus. Limitation of movement. Morning and inactivity stiffness, its duration and location. Other joints affected and its pattern of distribution.
History of other systems affections:
Neurological symptoms (muscle power and sensation of the lower limbs). Eye symptoms (redness, ulcers and blurred vision). Gastrointestinal tract (GIT) symptoms (diarrhea, heart burn and mucus in the stool). Urinary tract (UT) symptoms (dysuria and frequency). Skin affection (ulcers, erythema, papules and nodules).
4. Past history:
History of surgical operation of knee.
HistoryAssessment of range of motion of the affected knee joint:
For any limitation in the range of motion of the knee joint.
D) Special tests to assess ligaments and menisci:
Varus stress test for lateral collateral ligament. Valgus stress test for medial collateral ligament. Anterior drawer test for anterior cruciate ligament. Posterior drawer test for posterior cruciate ligament.
McMurry's test for menisci.Radiological investigations:
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Patients aged ≥ 40 years with symptoms of knee osteoarthritis
rheumatoid arthritis, spondyloarthropathy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description strontium ranelate physiotherapy included 15 patients who received oral strontium ranelate and physiotherapy program. The age of the patients ranged from 50 to 62 years, physiotherapy physiotherapy included 15 patients who received physiotherapy program. The age of the patients ranged from 50 to 62 years strontium ranelate Strontium Ranelate included 15 patients who received oral strontium ranelate and physiotherapy program. The age of the patients ranged from 50 to 62 years,
- Primary Outcome Measures
Name Time Method change of pain from base line immediately before intervention,3 monthes after intervention,6 monthes after intervention VAS pain is a uni-dimensional tool used to measure pain intensity. It is a 10 cm horizontal line marked every 1 cm. Pain intensity ranges from 0 (no pain, the left end of the line) to 10 (worst possible pain, the right end of the line). The following cut points on the pain VAS have been recommended: no pain (0-4 mm), mild pain (5- 44 mm), moderate pain (45-74 mm), and severe pain (75-100 mm)
- Secondary Outcome Measures
Name Time Method change of function from base line immediately before intervention,3 monthes after intervention,6 monthes after intervention Patients were assessed before treatment, at 3rd and 6th month after treatment using Western Ontario and McMaster Universities OA index (WOMAC). WOMAC is a self-administered composite questionnaire with three components to assess pain, knee stiffness and difficulty in the activity of daily living. Its first section contains 5 questions about pain, the second section includes 2 questions which assess knee stiffness and the last section is formed of 17 questions that measure the difficulty in the activity of daily living performance.
change of MRI findings from base line immediately before intervention and 6 monthes after intervention Assessment of knee joint by using semi-quantitative MRI by (MOAKS) MRI Osteoarthritis knee score which is performed
Trial Locations
- Locations (1)
Mansoura Uninersity Faculty of Medicine
🇪🇬Mansoura, Dakahlia Provence, Egypt