A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Crohn's Disease
- Conditions
- Crohn Disease
- Interventions
- Registration Number
- NCT05197049
- Lead Sponsor
- Janssen Research & Development, LLC
- Brief Summary
The purpose of this study is to evaluate the efficacy and safety of guselkumab in participants with Crohn's disease.
- Detailed Description
Crohn's disease is a chronic, progressive and potentially life-threatening disorder which may affect any part of the gastrointestinal (GI) tract. Guselkumab is a fully human immunoglobulin G1 lambda monoclonal antibody that binds to human interleukin (IL)-23, thereby blocking the binding of extracellular IL-23 to the cell surface IL-23 receptor. This binding results in inhibition of IL-23 mediated intracellular signaling, activation and cytokine production. The purpose of the study is to evaluate the efficacy and safety of guselkumab in participants with moderately to severely active Crohn's disease. The overall study duration is up to 109 weeks.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 350
- Diagnosis of Crohn's disease (CD) of at least 3 months in duration
- Have moderate to severe CD as assessed by CDAI, stool frequency, and abdominal pain score, and Simple Endoscopic Score for Crohn's disease (SES-CD).
- Demonstrated intolerance or inadequate response to conventional or to biologic therapy for CD
- Current diagnosis of ulcerative colitis or indeterminate colitis
- Complications of Crohn's disease that require surgical intervention or confound efficacy assessments
- Unstable doses of concomitant Crohn's disease therapy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group 1: Guselkumab Guselkumab Dose 2 Participants will receive guselkumab (Dose 1) injection subcutaneously followed by guselkumab (Dose 2) injection subcutaneously. Group 2: Guselkumab Guselkumab Dose 1 Participants will receive guselkumab (Dose 1) injection subcutaneously followed by guselkumab (Dose 3) injection subcutaneously. Group 1: Guselkumab Guselkumab Dose 1 Participants will receive guselkumab (Dose 1) injection subcutaneously followed by guselkumab (Dose 2) injection subcutaneously. Group 3: Placebo Placebo Participants will receive placebo injection subcutaneously. Group 2: Guselkumab Guselkumab Dose 3 Participants will receive guselkumab (Dose 1) injection subcutaneously followed by guselkumab (Dose 3) injection subcutaneously.
- Primary Outcome Measures
Name Time Method Percentage of Participants Who Achieved Clinical Remission at Week 12 At Week 12 Clinical remission was defined as a Crohn's Disease Activity Index (CDAI) score \<150. The multi-item CDAI score assessed severity of illness by collecting information on 8 different Crohn's disease-related variables (extraintestinal manifestations, abdominal mass, weight, hematocrit, use of antidiarrheal drug(s) and/or opiates, total number of liquid or very soft stools, abdominal pain/cramps, and general well-being). The last 3 variables were scored over 7 days by the participant on a diary card. The total CDAI score ranged from 0 (improvement in disease activity) to 600 (more disease activity) and a decrease in total CDAI score over time indicates improvement in disease activity.
Percentage of Participants Who Achieved Endoscopic Response at Week 12 At Week 12 Percentage of participants who achieved endoscopic response at Week 12 were reported. Endoscopic response was defined as greater than or equal to (\>=) 50 percent (%) improvement from baseline in the Simple Endoscopic Score for Crohn's Disease (SES-CD) score. SES-CD evaluated 4 endoscopic components (presence and size of ulcer, extent of ulcerated surface, extent of affected surface, and presence and type of narrowing) across 5 ileocolonic segments (ileum, right colon, transverse colon, left colon, and rectum), each scored from 0 (best) to 3 (worst) for each segment except narrowing component for which the maximum total score (that is, stricturing) was 11 points. The total SES-CD score was the sum of all the component scores across all the segments and it ranged from 0 (best) to 56 (worst), where higher scores indicated more severe disease.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Who Achieved Clinical Remission at Week 24 At Week 24 Percentage of participants who achieved clinical remission at Week 24 were reported. Clinical remission was defined as a Crohn's Disease Activity Index (CDAI) score \<150. The multi-item CDAI score assessed severity of illness by collecting information on 8 different Crohn's disease-related variables (extraintestinal manifestations, abdominal mass, weight, hematocrit, use of antidiarrheal drug(s) and/or opiates, total number of liquid or very soft stools, abdominal pain/cramps, and general well-being). The last 3 variables were scored over 7 days by the participant on a diary card. The total CDAI score ranged from 0 (improvement in disease activity) to 600 (more disease activity) and a decrease in total CDAI score over time indicates improvement in disease activity.
Percentage of Participants Who Achieved Patient-reported Outcome (PRO)-2 Remission at Week 12 At Week 12 Percentage of participants who achieved PRO-2 remission at Week 12 were reported. PRO-2 remission was defined as an abdominal pain (AP) mean daily score \<=1, and stool frequency (SF) mean daily score \<=3, and no worsening of AP or SF from baseline. Mean daily AP score based on the CDAI was defined as the sum of abdominal pain/cramps ratings in the previous 7 days in a diary card divided by the total number of days assessments were performed. Average daily SF score based on the CDAI was defined as the sum of number of liquid or very soft stools in the previous 7 days in a diary card divided by the total number of days assessments were performed. Mean daily SF and AP scores at a scheduled visit were not calculated if total number of days of assessment was less than 5. Higher PRO-2 scores indicated more severe disease.
Percentage of Participants Who Achieved Clinical Response at Week 12 At Week 12 Clinical response was defined as a decrease from baseline in CDAI score \>= 100 points or CDAI score \< 150. The multi-item CDAI score assessed severity of illness by collecting information on 8 different Crohn's disease-related variables (extraintestinal manifestations, abdominal mass, weight, hematocrit, use of antidiarrheal drug(s) and/or opiates, total number of liquid or very soft stools, abdominal pain/cramps, and general well-being). The last 3 variables were scored over 7 days by the participant on a diary card. The total CDAI score ranged from 0 (improvement in disease activity) to 600 (more disease activity) and a decrease in total CDAI score over time indicates improvement in disease activity.
Percentage of Participants With Treatment-Emergent Adverse Events (TEAEs) Through Week 48 Placebo, Guselkumab 400 mg + 100 mg, and Guselkumab 400 mg + 200 mg: From Week 0 up to Week 48; Placebo arm subset - Rescue Treatment: From Week 16 up to Week 48 Percentage of participants with TEAEs through Week 48 were reported. An adverse event (AE) was any untoward medical occurrence in a clinical study participant participating in a clinical study and does not necessarily have a causal relationship with the study drug. An AE that occurred at or after the initial administration of study drug (Week 0) through data cutoff of Week 48 was considered treatment-emergent.
Percentage of Participants With Treatment-Emergent Serious Adverse Events (TESAEs) Through Week 48 Placebo, Guselkumab 400 mg + 100 mg, and Guselkumab 400 mg + 200 mg: From Week 0 up to Week 48; Placebo arm subset - Rescue Treatment: From Week 16 up to Week 48 Percentage of participants with TESAEs through Week 48 were reported. An SAE was any untoward medical occurrence in a clinical study participant resulting in any of the following outcomes or was deemed significant for any other reason: death, life-threatening (immediate risk of dying), initial or prolonged inpatient hospitalization, persistent or significant disability/incapacity, congenital anomaly/birth defect. An AE does not necessarily have a causal relationship with the study drug. Any SAE that occurred at or after the initial administration of study drug (Week 0) through the data cutoff of Week 48 was considered treatment-emergent.
Percentage of Participants With Treatment-Emergent Adverse Events (TEAEs) Leading to Discontinuation of Study Drug Through Week 48 Placebo, Guselkumab 400 mg + 100 mg, and Guselkumab 400 mg + 200 mg: From Week 0 up to Week 48; Placebo arm subset - Rescue Treatment: From Week 16 up to Week 48 Percentage of participants with TEAEs leading to discontinuation of study drug through Week 48 were reported. An adverse event (AE) was any untoward medical occurrence in a clinical study participant participating in a clinical study and does not necessarily have a causal relationship with the study drug. An AE that occurred at or after the initial administration of study drug (Week 0) through data cutoff of Week 48 was considered treatment-emergent.
Trial Locations
- Locations (342)
Atlanta Center For Gastroenterology
🇺🇸Decatur, Georgia, United States
Gastroenterolgy Associates of Central GA
🇺🇸Macon, Georgia, United States
Gastroenterology Consultants
🇺🇸Roswell, Georgia, United States
USF Asthma, Allergy, Immunology Clinical Research Unit
🇺🇸Boise, Idaho, United States
Grand Teton Research Group, PLLC
🇺🇸Idaho Falls, Idaho, United States
Lemah Creek Clinical Research
🇺🇸Oakbrook Terrace, Illinois, United States
Crystal Run Healthcare LLP
🇺🇸Middletown, New York, United States
New York Gastroenterology Associates
🇺🇸New York, New York, United States
DiGiovanna Institute for Medical Education & Research
🇺🇸North Massapequa, New York, United States
A1 Clinical Network
🇺🇸Queens, New York, United States
Carolinas Medical Center
🇺🇸Charlotte, North Carolina, United States
Onsite Clinical Solutions
🇺🇸Charlotte, North Carolina, United States
CHU de Nice Hopital de l Archet
🇫🇷Nice, France
Hôpital Bichat
🇫🇷Paris, France
Hospices Civils de Lyon HCL
🇫🇷Pierre Bénite, France
Hôpital Robert Debré
🇫🇷Reims, France
Universitaetsklinikum Mannheim
🇩🇪Mannheim, Germany
Nishinomiya Municipal Central Hospital
🇯🇵Nishinomiya, Japan
Oita Red Cross Hospital
🇯🇵Oita, Japan
National Hospital Organization Osaka National Hospital
🇯🇵Osaka-shi, Japan
Kinshukai Infusion Clinic
🇯🇵Osaka, Japan
Japanese Red Cross Osaka Hospital
🇯🇵Osaka, Japan
National Taiwan University Hospital, Division of Infectious Diseases
🇨🇳Taipei, Taiwan
KO Med Centrum Medyczne
🇵🇱Straszow, Poland
Markusovszky Egyetemi Oktatokorhaz
🇭🇺Szombathely, Hungary
Vseobecna nemocnica Rimavska Sobota
🇸🇰Rimavska Sobota, Slovakia
Digestive Health Specialists of the Southeast
🇺🇸Dothan, Alabama, United States
Advanced Gastro P.C
🇺🇸Chandler, Arizona, United States
Reliance Research
🇺🇸Scottsdale, Arizona, United States
Moore Clinical Trials, LLC
🇺🇸Little Rock, Arkansas, United States
Central Arkansas Veterans Healthcare System
🇺🇸Little Rock, Arkansas, United States
Om Research LLC
🇺🇸Lancaster, California, United States
United Gastroenterologists
🇺🇸Los Alamitos, California, United States
Paul Wallace MD
🇺🇸Los Angeles, California, United States
Clinnova Research
🇺🇸Orange, California, United States
Digestive System Healthcare
🇺🇸Pasadena, California, United States
Gastroenterology Group Of Naples
🇺🇸Naples, Florida, United States
Center for Digestive Health
🇺🇸Orlando, Florida, United States
Central Florida Internists
🇺🇸Orlando, Florida, United States
Synergy Clinical Research
🇺🇸Saint Petersburg, Florida, United States
Atlanta Gastroenterology Specialists, PC
🇺🇸Atlanta, Georgia, United States
Agile Clinical Research Trials, LLC
🇺🇸Atlanta, Georgia, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
Institute for Digestive Health and Liver Disease
🇺🇸Baltimore, Maryland, United States
Dayton Gastroenterology, Inc
🇺🇸Dayton, Ohio, United States
Great Lakes Gastroenterology
🇺🇸Mentor, Ohio, United States
Oklahoma University Health Science Center
🇺🇸Oklahoma City, Oklahoma, United States
Hopital Erasme
🇧🇪Bruxelles, Belgium
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
Algemeen Ziekenhuis Delta
🇧🇪Roeselare, Belgium
University hospital Clinical centre Banja Luka
🇧🇦Banja Luka, Bosnia and Herzegovina
Clinical Center University of Sarajevo
🇧🇦Sarajevo, Bosnia and Herzegovina
Polyclinic Dr. Al-Tawil
🇧🇦Sarajevo, Bosnia and Herzegovina
General Hospital Tesanj
🇧🇦Tesanj, Bosnia and Herzegovina
Plava poliklinika Tuzla
🇧🇦Tuzla, Bosnia and Herzegovina
Cantonal Hospital Zenica
🇧🇦Zenica, Bosnia and Herzegovina
Universidade Estadual Paulista 'Julio De Mesquita Filho'
🇧🇷Botucatu, Brazil
CCB Centro Cardiologico de Brasilia Ltda - CCB Cardiologia
🇧🇷Brasilia, Brazil
Chronos Clinica Medica Ltda
🇧🇷Brasilia, Brazil
Sociedade Campineira de Educacao e Instrucao Hospital e Maternidade Celso Pierro
🇧🇷Campinas, Brazil
CDC - Centro Digestivo de Curitiba
🇧🇷Curitiba, Brazil
Universidade Federal Do Ceara
🇧🇷Fortaleza, Brazil
Centro de Estudos Clínicos do Interior Paulista - CECIP
🇧🇷Jau, Brazil
Cliged
🇧🇷Macae, Brazil
Liga Norte Riograndense Contra O Cancer
🇧🇷Natal, Brazil
Instituto Mederi de Pesquisa e Saude
🇧🇷Passo Fundo, Brazil
Guangzhou Medical University
🇨🇳Guangzhou, China
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine
🇨🇳Hangzhou, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, China
The First Affiliated Hospital of Anhui Medical University
🇨🇳Hefei, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
The First Hospital of Quanzhou
🇨🇳Quanzhou, China
Huashan Hospital Fudan University
🇨🇳Shanghai, China
Shanghai East Hospital
🇨🇳Shanghai, China
Shengjing Hospital Of China Medical University
🇨🇳Shenyang, China
The first affiliated hospital of suzhou University
🇨🇳Suzhou, China
Wuxi People s Hospital
🇨🇳Wuxi, China
Yangzhou First People's Hospital
🇨🇳Yangzhou, China
ZhuZhou Central Hospital
🇨🇳ZhuZhou, China
Opca bolnica Bjelovar
🇭🇷Bjelovar, Croatia
University Hospital Center Split
🇭🇷Split, Croatia
Opca bolnica Zadar
🇭🇷Zadar, Croatia
Poliklinika Solmed
🇭🇷Zagreb, Croatia
Fakultni nemocnice Brno
🇨🇿Brno, Czechia
Fakultni nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Oblastni nemocnice Kladno a.s.
🇨🇿Kladno, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Czechia
Nemocnice Slany
🇨🇿Slany, Czechia
Sydvestjysk Sygehus
🇩🇰Esbjerg, Denmark
Nordsjaellands Hospital - Hillerod
🇩🇰Hilleroed, Denmark
Centre Hospitalier de la Cote Basque
🇫🇷Bayonne, France
CHRU Besancon Hopital Jean Minjoz
🇫🇷Besancon Cedex, France
Hopital Louis Mourier
🇫🇷Colombes Cedex, France
CHU de Nantes hotel Dieu
🇫🇷Nantes, France
CHU Saint Etienne Hopital Nord
🇫🇷Saint-Priest en Jarez, France
CHRU Strasbourg
🇫🇷Strasbourg, France
CHU Rangueil
🇫🇷Toulouse, France
Gastroenterologische Spezialpraxis - Berlin-Karlshorst
🇩🇪Berlin-Karlshorst, Germany
Charite Universitatsmedizin Berlin, Campus Mitte (CCM) Allergie Center
🇩🇪Berlin, Germany
DRK Kliniken Westend
🇩🇪Berlin, Germany
Krankenhaus Waldfriede Mitte
🇩🇪Berlin, Germany
Staedtisches Klinikum Braunschweig
🇩🇪Braunschweig, Germany
Medizinisches Versorgungszentrum (MVZ) Dachau
🇩🇪Dachau, Germany
MVZ Sanaklinikum Duisburg
🇩🇪Duisburg, Germany
BSF Studiengesellschaft
🇩🇪Halle, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Praxisgemeinschaft Jerichow
🇩🇪Jerichow, Germany
Evangelisches Krankenhaus Kalk
🇩🇪Köln, Germany
Tumorzentrum Nordthüringen Medizinisches Versorgungszentrum
🇩🇪Nordhausen, Germany
Obudai Egeszsegugyi Centrum Kft
🇭🇺Budapest, Hungary
Egyesített Szent István és Szent László Kórház
🇭🇺Budapest, Hungary
Kagoshima IBD Gastroenterology Clinic
🇯🇵Kagoshima, Japan
Tsujinaka Hospital Kashiwanoha
🇯🇵Kashiwa, Japan
Kyushu Rosai Hospital
🇯🇵Kita-kyushu, Japan
Kobe University Hospital
🇯🇵Kobe, Japan
Yamanashi Prefectural Central Hospital
🇯🇵Kofu, Japan
Dokkyo Medical University Saitama Medical Center
🇯🇵Koshigaya, Japan
Hidaka Coloproctologic Clinic
🇯🇵Kurume, Japan
Japanese Red Cross Kyoto Daini Hospital
🇯🇵Kyoto, Japan
University Hospital Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Japan
Iwate Medical University Hospital
🇯🇵Morioka, Japan
Nagasaki University Hospital
🇯🇵Nagasaki, Japan
Yokoyama IBD Clinic
🇯🇵Nagoya, Japan
University of the Ryukyus Hospital
🇯🇵Nakagami-gun, Japan
Niigata University Medical And Dental Hospital
🇯🇵Niigata, Japan
Osaka General Medical Center
🇯🇵Osaka, Japan
Shiga University of Medical Science Hospital
🇯🇵Otsu, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Japan
Takagi Clinic
🇯🇵Sendai, Japan
Khalidi Hospital and Medical Center
🇯🇴Amman, Jordan
Kyungpook National University Chilgok Hospital
🇰🇷Busan, Korea, Republic of
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Korea, Republic of
Wonju Christian Hospital
🇰🇷Wonju, Korea, Republic of
Ewha Womans University Mokdong Hospital
🇰🇷YangCheon-Gu, Korea, Republic of
Lietuvos sveikatos mokslų universiteto ligoninė Kauno klinik
🇱🇹Kaunas, Lithuania
Vilnius University Hospital Santaros Klinikos, Public Institution
🇱🇹Vilnius, Lithuania
Hospital Sultanah Aminah
🇲🇾Johor Bharu, Malaysia
Hospital University Sains Malaysia
🇲🇾Kota Bharu, Malaysia
Ankara Numune Egitim ve Arastirma Hastanesi
🇹🇷Ankara, Turkey
Hacettepe University Hospital
🇹🇷Ankara, Turkey
Gazi University Medical Faculty
🇹🇷Ankara, Turkey
Acibadem Fulya Hospital
🇹🇷Istanbul, Turkey
Fundacao Universidade Federal do Piaui - Universidade Federal do Piaui
🇧🇷Teresina, Brazil
Integral Centro de Pesquisas Clinicas
🇧🇷Votuporanga, Brazil
Northshore Gastroenterology Research, LLC
🇺🇸San Diego, California, United States
Clinical Applications Laboratories, Inc
🇺🇸San Diego, California, United States
Santa Maria Gastroenterology
🇺🇸Santa Maria, California, United States
Clinical Research of California
🇺🇸Walnut Creek, California, United States
Amel Med LLC Research
🇺🇸Grand Junction, Colorado, United States
Western Connecticut Health Network/Danbury Hospital
🇺🇸Danbury, Connecticut, United States
Gastroenterology Associates of SW Florida
🇺🇸Clearwater, Florida, United States
Pioneer Research Solutions Inc.
🇺🇸Coconut Creek, Florida, United States
Omega Research Consultants
🇺🇸DeBary, Florida, United States
Harmony Medical Research Institute, Inc.
🇺🇸Hialeah, Florida, United States
Central Florida Gastro Research
🇺🇸Kissimmee, Florida, United States
Community Research Foundation, Inc.
🇺🇸Miami, Florida, United States
Hospital das Clinicas de Porto Alegre
🇧🇷Porto Alegre, Brazil
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
BVL Clinical Research
🇺🇸Leawood, Kansas, United States
Cotton O'Neil Digestive Health Center
🇺🇸Topeka, Kansas, United States
Tri-State Gastroenterology Assoc
🇺🇸Crestview Hills, Kentucky, United States
Woodholme Gastroenterology Associates
🇺🇸Glen Burnie, Maryland, United States
Digestive Health Specialists PC
🇺🇸Chelmsford, Massachusetts, United States
FC Research, LLC
🇺🇸South Dartmouth, Massachusetts, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Chesterfield, Michigan, United States
Detroit Clinical Research Center
🇺🇸Livonia, Michigan, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
SUNY Downstate Medical Center
🇺🇸Brooklyn, New York, United States
Smart Medical Research
🇺🇸Jackson Heights, New York, United States
Carolina Research
🇺🇸Greenville, North Carolina, United States
Gastroenterology Associates of the Piedmont, P.A.
🇺🇸Winston-Salem, North Carolina, United States
Central Ohio Endoscopy Center LLC
🇺🇸Columbus, Ohio, United States
Integris Baptist Office
🇺🇸Oklahoma City, Oklahoma, United States
Central Sooner Research
🇺🇸Oklahoma City, Oklahoma, United States
Essential Medical Research
🇺🇸Tulsa, Oklahoma, United States
The Oregon Clinic
🇺🇸Portland, Oregon, United States
Frontier Clinical Research
🇺🇸Smithfield, Pennsylvania, United States
Gastroenterology Associates P.A.
🇺🇸Greenville, South Carolina, United States
Carolina Health Specialists
🇺🇸Myrtle Beach, South Carolina, United States
West Texas Clinical Research
🇺🇸Lubbock, Texas, United States
Victoria Gastroenterology
🇺🇸Richmond, Texas, United States
Gastroenterology Clinic Of San Antonio P A
🇺🇸San Antonio, Texas, United States
Wellness Clinical Research
🇺🇸San Antonio, Texas, United States
Texas Digestive Disease Consultants
🇺🇸Southlake, Texas, United States
Digestive Health Specialists of Tyler
🇺🇸Tyler, Texas, United States
Care Access Research- Salt Lake City
🇺🇸Salt Lake City, Utah, United States
Burke Internal Medicine and Research
🇺🇸Burke, Virginia, United States
Gastroenterology Associates of Tidewater
🇺🇸Chesapeake, Virginia, United States
Monash Health, Monash Medical Centre
🇦🇺Clayton, Australia
Coral Sea Clinical Research Institute
🇦🇺North Mackay, Australia
OLV Ziekenhuis Aalst
🇧🇪Aalst, Belgium
CHU Saint-Pierre
🇧🇪Bruxelles, Belgium
Associacao Hospitalar Moinhos de Vento
🇧🇷Porto Alegre, Brazil
Associacao dos Funcionarios Publicos do Estado do Rio Grande do Sul - Hospital Ernesto Dornelles
🇧🇷Porto Alegre, Brazil
NPCRS Nucleo de Pesquisa Clinica do Rio Grande do Sul
🇧🇷Porto Alegre, Brazil
Hospital das Clinicas - Universidade Federal de Pernambuco
🇧🇷Recife, Brazil
Universidade Federal da Bahia - Hospital Professor Edgard Santos
🇧🇷Salvador, Brazil
SER - Servicos Especializados em Reumatologia da Bahia
🇧🇷Salvador, Brazil
Pesquisare Saude
🇧🇷Santo Andre, Brazil
Irmandade da Santa Casa da Misericórdia de Santos
🇧🇷Santos, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
🇧🇷Sao Jose do Rio Preto, Brazil
BR TRIALS Ensaios Clinicos e Consultoria Ltda
🇧🇷Sao Paulo, Brazil
Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE
🇧🇷Sao Paulo, Brazil
Hepatogastro
🇧🇷Sao Paulo, Brazil
CEMEC - Centro Multidisciplinar de Estudos Clínicos
🇧🇷São Bernardo do Campo, Brazil
Kaiser Hospta
🇧🇷São José Do Rio Preto, Brazil
Instituto D Or de Pesquisa e Ensino IDOR
🇧🇷São Paulo, Brazil
London Health Sciences Centre
🇨🇦London, Ontario, Canada
North Bay Dermatology Centre
🇨🇦North Bay, Ontario, Canada
The Affiliated Hospital of Bengbu Medical College
🇨🇳Bengbu, China
Xiangya Hospital Central South University
🇨🇳Changsha, China
The second Xiangya Hospital of Central South University
🇨🇳Changsha, China
Changzhou No 2 Peoples Hospital
🇨🇳Changzhou City, China
West China Hospital Sichuan University
🇨🇳Chengdu, China
The First People's Hospital of Foshan
🇨🇳China, China
Chongqing Medical University
🇨🇳Chongqing, China
The First Affiliated Hospital of Fujian Medical University
🇨🇳Fuzhou, China
First Affiliated Hospital of Gannan Medical University
🇨🇳Ganzhou, China
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, China
Guangzhou First Municipal People's Hospital
🇨🇳GuangZhou, China
The First Affiliated Hospital of NanChang University
🇨🇳Nanchang, China
Nanjing 1st Hospital
🇨🇳Nanjing, China
Eszak Kozep budai Centrum Uj Szent Janos Korhaz es Szakrendelo Budai Csaladkozpontu
🇭🇺Budapest, Hungary
Mh Egészségügyi Központ
🇭🇺Budapest, Hungary
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Pannónia Magánorvosi Centrum Kft
🇭🇺Budapest, Hungary
Pest Megyei Flor Ferenc Korhaz
🇭🇺Kistarcsa, Hungary
Mohacsi Korhaz
🇭🇺Mohacs, Hungary
Pecsi Tudomanyegyetem Orvostudomanyi Es Egeszsegtudomanyi Centrum, I. Belgyogyaszati Klinika
🇭🇺Pecs, Hungary
Haemek Medical Center
🇮🇱Afula, Israel
Soroka University Medical Center
🇮🇱Beer-Sheva, Israel
The Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
Assaf Harofeh Medical Center
🇮🇱Tzrifin, Israel
Policlinico Sant'Orsola Malpighi
🇮🇹Bologna, Italy
Istituto Clinico Humanitas Rozzano, IRCCS
🇮🇹Milano, Italy
Università Campus Biomedico di Roma
🇮🇹Roma, Italy
Juntendo University Hospital
🇯🇵Bunkyo-ku, Japan
Ginza central clinic
🇯🇵Chuo-ku, Japan
Fukui Prefectural Hospital
🇯🇵Fukui-ken, Japan
Fukuoka University Hospital
🇯🇵Fukuoka, Japan
Japanese Red Cross Fukuoka Hospital
🇯🇵Fukuoka, Japan
National Hospital Organization Fukuyama Medical Center
🇯🇵Fukuyama, Japan
Gamagori City Hospital
🇯🇵Gamagori, Japan
Gunma University Hospital
🇯🇵Gunma, Japan
Hachinohe City Hospital
🇯🇵Hachinohe, Japan
Matsuda Hospital
🇯🇵Hamamatsu-shi, Japan
Hamamatsu University Hospital
🇯🇵Hamamatsu, Japan
National Hospital Organization Mito Medical Center
🇯🇵Higashi-Ibaraki, Japan
Kure Kyosai Hospital
🇯🇵Hiroshima, Japan
National Hospital Organization Shikoku Cancer Center
🇯🇵Iizuka-shi, Japan
Kagoshima University Hospital
🇯🇵Kagoshima, Japan
Twoja Przychodnia - Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
Sonomed Sp. z o.o.
🇵🇱Szczecin, Poland
National Hospital Organization Shizuoka Medical Center
🇯🇵Sunto-gun, Japan
Tokyo Medical University Hospital
🇯🇵Tokyo, Japan
Toyota Kosei Hospital
🇯🇵Toyota, Japan
Yokohama City University Medical Center
🇯🇵Yokohama, Japan
The Speciality Hospital (TSH) / Advanced Clinical Center
🇯🇴Amman, Jordan
Istiklal Hospital
🇯🇴Amman, Jordan
Abdali Hospital
🇯🇴Amman, Jordan
Irbid Specialty Hospital
🇯🇴Irbid, Jordan
King Abdullah University Hospital
🇯🇴Irbid, Jordan
Kosin University Gospel Hospital
🇰🇷Busan, Korea, Republic of
DongA Medical Center
🇰🇷Busan, Korea, Republic of
Yeungnam University Medical Center
🇰🇷Daegu, Korea, Republic of
The Catholic University of Korea Seoul St.Mary's Hospital
🇰🇷Daejeon, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Dongdaemun-gu, Korea, Republic of
Dongguk University Ilsan Hospital
🇰🇷Goyang-si, Korea, Republic of
Chonnam National University Hospital
🇰🇷Gwangju, Korea, Republic of
The Catholic university of Korea, St. Vincent's Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
CHA Bundang Medical Center, CHA University
🇰🇷Gyeonggi, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Yonsei University College of Medicine
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea Seoul St Mary s Hospital
🇰🇷Seoul, Korea, Republic of
Hospital Raja Permaisuri Bainun
🇲🇾Kota Kinabalu, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
Hospital Tengku Ampuan Afzan
🇲🇾Kuantan, Malaysia
Onze Lieve Vrouwe Gasthuis
🇳🇱Amsterdam, Netherlands
Sint Franciscus Gasthuis
🇳🇱Rotterdam, Netherlands
Elisabeth-TweeSteden Ziekenhuis
🇳🇱Tilburg, Netherlands
Christchurch Hospital
🇳🇿Christchurch, New Zealand
Dunedin Hospital
🇳🇿Dunedin, New Zealand
Gastromed Kralisz Romatowski Stachurska Sp. j.
🇵🇱Bialystok, Poland
10 Wojskowy Szpital Kliniczny z Poliklinika, SP ZOZ
🇵🇱Bydgoszcz, Poland
Centrum Medyczne Lukamed
🇵🇱Chojnice, Poland
Sahlgrenska University Hospital
🇵🇱Chrzanow, Poland
Private Practice - Dr. Krzysztof Cymerman
🇵🇱Gdynia, Poland
Centrum Medyczne Clw-Med Aneta Cichomska i Joanna Luka-Wendrowska sp.j.
🇵🇱Grudziadz, Poland
Malopolskie Centrum Kliniczne
🇵🇱Krakow, Poland
Centrum Medyczne Plejady
🇵🇱Krakow, Poland
Centrum Medyczne ProMiMed
🇵🇱Krakow, Poland
AmiCare Centrum Medyczne
🇵🇱Lodz, Poland
IP Clinic Sp. z o.o.
🇵🇱Lodz, Poland
Centrum Medyczne Med Gastr
🇵🇱Lodz, Poland
ETG Lublin
🇵🇱Lublin, Poland
Niepubliczny Zaklad Opieki Zdrowotnej
🇵🇱Lublin, Poland
Allmedica
🇵🇱Nowy Targ, Poland
Wojewodzki Szpital Specjalistyczny w Olsztynie
🇵🇱Olsztyn, Poland
Twoja Przychodnia
🇵🇱Poznan, Poland
Centrum Medyczne
🇵🇱Piotrkow Trybunalski, Poland
EMC Instytut Medyczny SA PL CERTUS
🇵🇱Poznan, Poland
Synexus Polska Sp z o o
🇵🇱Poznan, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Poland
Centrum Medyczne Promed
🇵🇱Skorzewo, Poland
Endoskopia Sp z o.o.
🇵🇱Sopot, Poland
Kiepury Clinic
🇵🇱Sosnowiec, Poland
GASTROMED Kopon Zmudzinski i wspolnicy SP j Specjalistyczne Centrum Gastrologii i Endoskopii
🇵🇱Torun, Poland
H-T Centrum Medyczne Endoterapia
🇵🇱Tychy, Poland
Endoterapia
🇵🇱Warsaw, Poland
Centrum Zdrowia Matki Dziecka i Mlodziezy
🇵🇱Warszawa, Poland
Medical Concierge Centrum Medyczne
🇵🇱Warszawa, Poland
Centralny Szpital Kliniczny MSWiA w Warszawie
🇵🇱Warszawa, Poland
NZOZ Vivamed
🇵🇱Warszawa, Poland
Gabinety Lekarskie Bodyclinic
🇵🇱Warszawa, Poland
IBD Point Profesor Kierkus
🇵🇱Warszawa, Poland
Centrum Zdrowia Tuchow
🇵🇱Wierzchoslawice, Poland
Centrum Diagnostyczno - Lecznicze Barska sp. z o.o. Szpital Specjalistyczny Barska
🇵🇱Wloclawek, Poland
Melita Medical Sp. z o.o.
🇵🇱Wroclaw, Poland
Centrum Medyczne Melita Medical
🇵🇱Wroclaw, Poland
Uniwersytecki Szpital Kliniczny im. J. Mikulicza-Radeckiego
🇵🇱Wroclaw, Poland
Przychodnia Vistamed
🇵🇱Wroclaw, Poland
ETG Zamosc
🇵🇱Zamosc, Poland
FNsP F.D.R. Banska Bystrica
🇸🇰Banska Bystrica, Slovakia
ENDOMED s.r.o
🇸🇰Kosice, Slovakia
GASTRO I. s.r.o.
🇸🇰Presov, Slovakia
Hosp. de Cabuenes
🇪🇸Gijón, Spain
Hosp. Gral. Juan Ramon Jimenez
🇪🇸Huelva, Spain
Hosp. Univ. Infanta Leonor
🇪🇸Madrid, Spain
Hosp. Virgen Macarena
🇪🇸Sevilla, Spain
Hosp. Alvaro Cunqueiro
🇪🇸Vigo, Spain
Hosp. de La Marina Baixa
🇪🇸Villajoyosa, Spain
Kaohsiung Medical University Chung Ho Memorial Hospital
🇨🇳Kaoshiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taipei Medical University
🇨🇳Taipei, Taiwan
Linkou Chang Gung Memorial Hospital
🇨🇳Taoyuan, Taiwan
Ege Universitesi Tip Fakultesi
🇹🇷Izmir, Turkey
Mersin University Medical Faculty
🇹🇷Mersin, Turkey
Ondokuz Mayis University
🇹🇷Samsun, Turkey
Bülent Ecevit Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi
🇹🇷Zonguldak, Turkey