Transcranial Magnetic Stimulation of the Prefrontal Cortex: Effects on Risky Decision Making and Temporal Discounting.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Withdrawn
- Sponsor
- University of Arkansas
- Primary Endpoint
- The k metric of a hyperbolic function for delayed discounting
Study Overview
Brief Summary
The main objective of this study is to examine the effects of magnetic stimulation on the prefrontal cortex. We plan to use low frequency, repeated transcranial magnetic stimulation (1 Hz rTMS) to temporarily inhibit activity in the prefrontal cortex and measure the resulting effect on two decision-making tasks. The prefrontal cortex is thought to mediate or control cognitive functions like decision-making, planning, memory, and inhibit impulsive behavior.Previous research has indicated that rTMS over the right dorsal lateral prefrontal cortex will lead to preferences for riskier alternatives. Our hypothesis is that rTMS over the right DLPFC will lead to greater preference for the riskier alternative and greater temporal discounting.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy participants willing to give informed consent to participate
- •complete the Transcranial magnetic stimulation Adult Safety Screen
- •have a MRI scan
- •wear ear plugs during rTMS
- •receive rTMS over the designated course of days
- •complete cognitive assessments and decision making tasks.
- •return for post-testing on all tasks after completing all rTMS sessions
Exclusion Criteria
- •Diagnosed neurological and/or psychiatric disorders requiring hospitalization or medication
- •pregnancy or the possibility of pregnancy at the time of consent
- •a history of tinnitus
- •metal implants in head or neck or a pacemaker
- •poorly-controlled migraines
- •a history of head injury, stroke, previous brain neurosurgery, or loss of consciousness due to head injury lasting greater than 10 minutes
- •a personal or family history of epilepsy or seizures
Outcomes
Primary Outcomes
The k metric of a hyperbolic function for delayed discounting
Time Frame: 12-18 weeks
Secondary Outcomes
No secondary outcomes reported