The effect of Vitamin D Supplement on Insulin Resistance and Prevention of Diabetes Mellitus Type 2 in Patients with Pre-diabetes
Phase 3
- Conditions
- pre-diabetes (IFG or IGT).Impaired glucose toleranceR73.0Diabetes: chemical latent Impaired glucose tolerance Prediabetes
- Registration Number
- IRCT2013050413223N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
adult patients who are over 18 years old; pre-diabetes (IFG or IGT) and vitamin-D deficiency; obtaine informed consent.
Exclusion criteria: overt Diabetes Mellitus; condition which interfere with glucose metabolism (malignancy, CRF, , inflammatory disease...); diseases like thyroid disease or mal-absorption; take medication that interfere with glucose metabolism (Steroids, HRT,Diuretics).
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diabetes(75gr-OGTT):Assessment of fasting plasma glucose after at least 8-hours fasting then 2 hours after administration of 75 gram glucose, Insulin resistance evaluated by calculating HOMA-IR. Timepoint: Befor intervention, 3 and 6 months after intervention. Method of measurement: Fasting plasma sample for evaluation of FPG and Serum insulin,Oral glucose tolerance test(OGTT) with 75gr glucose.
- Secondary Outcome Measures
Name Time Method Height, weight, BMI, weist circmfrence. Timepoint: Every 3 month. Method of measurement: height (cm), weight (kg), BMI (kg/squired meters), weist circmfrence(cm).