Appetite Response to Exercise- Versus Mixed (Exercise + Dietary Restriction)-Induced Energy Deficit in Adolescents With Obesity

Not Applicable

Completed

• Conditions: Pediatric Obesity
• Interventions: Behavioral: CON . control condition without exercise / rest condition; Behavioral: Def-Mixed. Condition with a mixed energy deficit induced by exercise + dietary restriction.; Behavioral: Def-EI. Condition with an energy-restriction energy deficit

• Registration Number: NCT04734639
• Lead Sponsor: University Hospital, Clermont-Ferrand

Brief Summary

The aim of the present study is to compare the effect of iso-energetic energy deficits induced by energy restriction alone or exercise + dietary restriction (Mixed deficit) on energy intake and appetite feelings in adolescents with obesity.

Detailed Description

The present study will compare the nutritional response to an energy deficit of 500 kcal induced once by dietary restriction alone and once by a mixed deficit (50% by exercise and 50% by dietary restriction) (compared with a control condition). 18 adolescents with obesity will be asked to randomly complete three experimental sessions: i) one control session (CON); ii) one session with a dietary-induced energy deficit (Def-EI); iii) one session with a mixed deficit (50% by exercise and 50% by dietary restriction) (Def-Mixed).

Their ad libitum energy intake will be assessed at dinner time. Appetite feelings will be assessed at regular intervals and their food reward in response to the lunch will also be assessed.

Study Timeline

• Study First Submitted: 2021-01-27
• Study First Submitted QC: 2021-02-01
• Study First Posted: 2021-02-02
• Study Start: 2021-04-24
• Primary Completion: 2021-06-30
• Study Completion: 2021-06-30
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-30
• Last Update Posted: 2021-10-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

• BMI percentile > 97th percentile according to the french curves.
• ages 12-16 years old
• Signed consent form
• being registered in the national social security system
• no contraindication to physical activity

Exclusion Criteria

• Previous surgical interventions that is considered as non-compatible with the study.
• Diabetes
• weight loss during the last 6 months
• cardiovascular disease or risks

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Obese adolescents	CON . control condition without exercise / rest condition	20 adolescents with obesity are involved and will perform the three conditions.
Obese adolescents	Def-EI. Condition with an energy-restriction energy deficit	20 adolescents with obesity are involved and will perform the three conditions.
Obese adolescents	Def-Mixed. Condition with a mixed energy deficit induced by exercise + dietary restriction.	20 adolescents with obesity are involved and will perform the three conditions.

Primary Outcome Measures

Name	Time	Method
Change from different intervention of energy intake measured during an ad libitum buffet meal (in kcal).	day 1, day 8, day 15	food intake will be measured ad libitum during a dinner buffet. The adolescents will be offered an ad libitum buffet-type meal composed based on their food intake preferences. Their intake will be weighted using an electronic food scale by a member of the investigation team and then analysed using Bilnuts software.

Secondary Outcome Measures

Name	Time	Method
Hunger feelings	day 1, day 8, day 15	hunger area under the curve will be assessed using visual analogue scale through a the day
Food reward	day 1, day 8, day 15	The participants will be asked to complete a validated computer-based procedure to measure food reward (Leeds Food Preference Questionnaire; LFPQ) (Finlayson, King et al. 2008).

Trial Locations

Locations (1)

Chu Clermont Ferrand; 🇫🇷 Clermont-Ferrand, France