Effects of growth hormone (GH) replacement therapy in GH deficient adult childhood cancer survivors on organ size and microvascularisation of kidney and skin.
- Conditions
- growth hormone deficiency1002111210038430
- Registration Number
- NL-OMON33094
- Lead Sponsor
- ovo Nordisk
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
childhood cancer survivors who have been treated with cranial irradiation
growth hormone deficient
age > 18 years
> 5 years off tumor treatment
Exclusion Criteria
growth hormone replacement therapy in the last 12 months
current treatment for second malignancy
severe mental disorder/dementia/inability of legal consent
drug abuse/dependence
for women: pregnancy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. Change in visceral organ size, especially kidney size.<br /><br>2. Change in GFR and ERPF.<br /><br>3. Change in capillary density of the skin.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Change in quality of life.</p><br>