A clinical trial to study effect of bupivacaine for post operative pain in patients undergoing surgery for gall stone disease laparoscopically

Not yet recruiting

• Conditions: ADULT PATIENTS OF EITHER SEX, SCHEDULED FOR ELECTIVE LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA

• Registration Number: CTRI/2019/02/017802
• Lead Sponsor: SWATI PANWAR

Brief Summary

Effective post operative analgesia after laparoscopic cholecystectomy remains a clinical challenge. Recently, instillation of different local anaesthetics (LAs) intraperitoneally has gained popularity for post-operative analgesia in laparoscopic cholecystectomy. Most of the studies have used bupivacaine irrigation of peritoneal cavity in low volume(20ml to 100ml) and high concentration(0.125%-0.5%). However, their analgesic action is effective for only a few hours in the post-operative period.

Recently low concentration(0.02%)  but high volume (500 ml) of bupivacaine has been used for intraperitoneal irrigation in order to cover large sub hepatic area and surrounding peritoneum thereby producing more effective analgesia. It significantly increased duration of analgesia and reduced opioid requirement after laparoscopic cholecystectomy.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-02-24
• Study Start: 2019-02-28

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• ASA PHYSICAL STATUS I/II 2.
• SCHEDULED FOR ELECTIVE LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA.

Exclusion Criteria

• ALLERGY TO LOCAL ANAESTHETICS 2.
• ACUTE PANCREATITIS 3.
• CHOLEDOCHOLITHIASIS 4.
• CURRENT ANALGESIC USE 5.
• INABILITY TO COMPREHEND NRS( NUMERIC PAIN RATING SCALE) 6.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
DURATION OF ANALGESIA	time interval between removal of airway device and first requirement of rescue analgesic

Secondary Outcome Measures

Name	Time	Method
-NUMERIC PAIN RATING SCALE	-TOTAL DOSE OF RESCUE

Trial Locations

Locations (1)

MAULANA AZAD MEDICAL COLLEGE; 🇮🇳 Delhi, DELHI, India

MAULANA AZAD MEDICAL COLLEGE

🇮🇳Delhi, DELHI, India

DR SWATI PANWAR

Principal investigator

9873774094

panwarswati182@gmail.com