Efficacy of high-volume low- concentration intraperitoneal bupivacaine irrigation for post operative analgesia in patients undergoing laparoscopic cholecystectomy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- DURATION OF ANALGESIA
Study Overview
Brief Summary
Effective post operative analgesia after laparoscopic cholecystectomy remains a clinical challenge. Recently, instillation of different local anaesthetics (LAs) intraperitoneally has gained popularity for post-operative analgesia in laparoscopic cholecystectomy. Most of the studies have used bupivacaine irrigation of peritoneal cavity in low volume(20ml to 100ml) and high concentration(0.125%-0.5%). However, their analgesic action is effective for only a few hours in the post-operative period.
Recently low concentration(0.02%) but high volume (500 ml) of bupivacaine has been used for intraperitoneal irrigation in order to cover large sub hepatic area and surrounding peritoneum thereby producing more effective analgesia. It significantly increased duration of analgesia and reduced opioid requirement after laparoscopic cholecystectomy.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 20.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •ASA PHYSICAL STATUS I/II
- •SCHEDULED FOR ELECTIVE LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA.
Exclusion Criteria
- •ALLERGY TO LOCAL ANAESTHETICS
- •ACUTE PANCREATITIS
- •CHOLEDOCHOLITHIASIS
- •CURRENT ANALGESIC USE
- •INABILITY TO COMPREHEND NRS( NUMERIC PAIN RATING SCALE) 6.
Outcomes
Primary Outcomes
DURATION OF ANALGESIA
Time Frame: time interval between removal of airway device and first requirement of rescue analgesic
Secondary Outcomes
- -NUMERIC PAIN RATING SCALE(-TOTAL DOSE OF RESCUE)