Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes Following a Sports Camp
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Changes in epinephrine serum level.
研究概览
简要总结
One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events. During sports camps, due to the accumulation of a large number of training units, including high-intensity exercises, athletes react with post-exercise overload, acute fatigue, and overreaching which can become a chronic overtraining syndrome. Overtraining syndrome is a very specific and severe condition where overtraining without adequate rest and recovery leads to performance decrements lasting more than 2-3 months, coupled with a mood disturbance. The exact etiology and pathogenesis are unknown and actively being investigated.
During training camps the balance between training volumes and recovery is often a delicate one and, the accumulation of exercise-induced stress may exceed the capacity of both neuroendocrine and immune adaptation leading to an alteration of physiological functions, decreasing adaptation to performance, impairment of psychological processing, immunological dysfunction, and biochemical abnormalities. Moreover, there is currently a lack of biomarkers accessible to assist in diagnosing and, what's even more important - help to prevent the overtraining syndrome, except for the continued presence of unexplained underperformance despite athletes' adequate rest and recovery.
Thus, this study aims to explain how long and intensive training for endurance affects the hormonal and immune systems of young athletes.
The main questions it aims to answer are:
- How does intense training influence hormonal and immune responses in young, trained athletes?
- Does training specialization affect the hormonal and immune response to intense training?
详细描述
Twenty-four young male and female athletes, specializing in athletics disciplines such as sprint (hurdles, 100m, 110m), and endurance: race walk, 5000m, and 10000m, volunteered to take part in this study. Investigation was held during 9 days of the training camp (preparatory period, general preparation sub-period), which was aimed at increasing the endurance and flexibility of athletes. During the training camp, all subjects occupied the same accommodations and followed the same training plan and diet schedules. The camp regime included 2 training sessions per day, lasting 4 hours per day, and a total of 21 hours per 9 days. Blood samples were taken always in the same conditions, from the antecubital veins. Participants were seated in a recumbent position for a minimum of 10 minutes before blood draws to stabilize the hydrostatic condition. Before collection of the first sample (rested baseline), participants were asked to avoid any intense exercise at least 24 hours before sampling. Next samples were taken after 4 days and after another 5 days of training camp (in total after 9 days). The concentration of catecholamines: epinephrine and norepinephrine in serum was measured as well and the responsiveness of the adrenal medulla to the sympathetic nervous activity was estimated by the ratio E/NE calculated. Also, concentrations of cortisol, hs-CRP, and myoglobin were measured and changes in blood morphology were estimated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 15-17 years,
- •minimum of 3 years of training experience,
- •specialization in anaerobic and aerobic disciplines.
排除标准
- •presence of acute or chronic inflammation
- •fever, infections, injuries
- •se of any anti-inflammatory drugs.
结局指标
主要结局
Changes in epinephrine serum level.
时间窗: at rest baseline (before training), after 4 - and after another 5 days of training.
marker of HPA axis functioning, stress hormone.
Changes in norepinephrine serum level.
时间窗: at rested baseline (before training), after 4 - and after another 5 days of training.
marker of HPA axis functioning, stress hormone.
Changes in cortisol serum level.
时间窗: at rested baseline (before training), after 4 - and after another 5 days of training.
marker of HPA axis functioning, stress hormone
Changes in hs-CRP serum level.
时间窗: at rested baseline (before training), after 4 - and after another 5 days of training.
marker of inflammatory response.
Changes in Myoglobin serum level.
时间窗: at rested baseline (before training), after 4 - and after another 5 days of training.
marker of muscle damage
次要结局
- Changes in blood morphology.(sat rested baseline (before training), after 4 - and after another 5 days of training.)
- Changes in epinephrine/norepinephrine ratio.(at rested baseline (before training), after 4 - and after another 5 days of training.)