Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- Total matrix metalloproteinase 9 (MMP-9) level in dentinal fluid
研究概览
简要总结
The purpose of this study is to determine whether dentinal fluid (tooth fluid) of teeth with or without a painful inflammatory condition in their nerve (pulp) contain inflammatory marker.
详细描述
Objective:
The aim of the study is to use an improved sampling method for collection of MMP-9 to test the hypothesis that MMP-9 levels are significantly elevated in the dentinal fluid of symptomatic (painful) human permanent teeth compared to asymptomatic counterparts that need replacement of a filling, and pulp necrotic teeth. Moreover, the dynamics of MMP-9 expression after removal of the causative stimulus for pulpitis is to be investigated.
Outcome:
Measuring the total MMP-9 levels of dentinal fluid collected during dental treatment using a human MMP-9 fluorescent assay.
Measurements and procedures:
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients who attend the University of Zurich, Center of Dental Medicine, Clinic of Preventive Dentistry, Periodontology and Cariology that are in need for
- •Treatment of pain related to pulpal inflammation
- •Caries therapy
- •Root canal treatment of a pulp-necrotic tooth
- •Replacement of an defect/fractured filling
排除标准
- •Children or adolescents (≤18 y)
- •Patients who do not agree to participate in the study
- •Patients with general diseases of inflammatory nature (such as diabetes, Crohn's disease, etc), or diseases affecting the immune-system (immuno-suppression, multiple morbidities, etc.)
- •Women with known pregnancy
- •Patients not fluent in German or English language
- •Patients who had antibiotic or NSAID intake during the last 14 days
- •Patients who refuse to be examined radiographically.
结局指标
主要结局
Total matrix metalloproteinase 9 (MMP-9) level in dentinal fluid
时间窗: Immediately
次要结局
未报告次要终点