Chlorhexidine Gluconate Versus Saline for Flushing the Surgical Area During Colorectal Cancer Surgery

Not Applicable

Recruiting

• Conditions: Colorectal Cancer; Surgical Site Infection; Chlorhexidine; Complications

• Registration Number: NCT06869096
• Lead Sponsor: Nanchong Central Hospital

Brief Summary

The aim of this study was to compare the effectiveness of chlorhexidine versus saline in flushing the surgical area during colorectal cancer surgery. The primary outcomes included surgical site infection, postoperative complication rates, et al.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-02
• Status Verified: 2024-10
• Study First Submitted: 2025-03-10
• Study First Submitted QC: 2025-03-10
• Study First Posted: 2025-03-11
• Last Update Submitted: 2025-03-17
• Last Update Posted: 2025-03-20
• Primary Completion: 2025-12-31
• Study Completion: 2026-03-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 532

Inclusion Criteria

1. Patients aged 18-85 years,
2. Patients with surgically resectable colorectal tumors confirmed by CT/MRI before surgery
3. All patients had a performance status score of 0 or 1 in the Eastern Tumor Cooperative group
4. American Society of Anesthesiology grade I-III

Exclusion Criteria

1. The tumor may have distant metastasis
2. History of previous abdominal surgery
3. The patient has a history of other malignant tumors diagnosed in the past 5 years and has received radiotherapy and chemotherapy in the past
4. There are obvious contraindications to surgery (obvious abnormal liver and kidney function, pregnancy)
5. Participated in other clinical trials within the past 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Number of participants with Surgical site infection within 30 days	30 days	Any surgical site infection within 30 days of surgery is classified as superficial incision, deep mouth, or organ space infection according to the U.S. Centers for Disease Control and Prevention standards.

Secondary Outcome Measures

Name	Time	Method
Number of participants with Postoperative complication within 30 days	30 days	Including anastomotic fistula, anastomotic hemorrhage, intestinal obstruction, deep vein thrombosis and so on

Trial Locations

Locations (1)

Nanchong Central Hospital; 🇨🇳 Nanchong, Sichuan, China