Effects of a Single-bout of Moderate-intensity Aerobic Exercise on Mood and Mental Health Biomarkers in Adults with Depressive And/or Anxiety Symptoms
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Profile of Mood States (POMS)
研究概览
简要总结
This study investigates whether a single session of aerobic exercise (like running) can improve the participants' mood and whether such benefits can be explained by changes in the blood factors (like hormones) and brain activity.
The main questions this study aims to answer are:
- Can a single session of aerobic exercise improve mood?
- Which changes in the blood and brain could explain the effects of exercise on mood?
Researchers will compare the participants' mood states before and after exercise to see whether exercise can improve mood.
The participants will:
- Answer questionnaires, collect blood, and undergo magnetic resonance imaging (MRI) before exercise.
- Perform 30 minutes of running on a treadmill.
- Answer the same questionnaires, collect blood, and undergo magnetic resonance imaging (MRI) after exercise.
The entire assessment will last for about 2h45min and will be performed on a single day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects within the stipulated age range
排除标准
- •Acute injury or illness that impairs the ability to safely exercise and/or inability to exercise with a moderate intensity;
- •Metabolic and/or neurologic disorders;
- •Iron implants;
- •People who cannot stay still, are intolerant of noise or fearful of enclosed spaces (due to the small space inside the scanner).
研究组 & 干预措施
Moderate-intensity aerobic exercise
Thirty minutes of exercise on a treadmill, including a 5-minute warm-up followed by increments in speed until reaching optimal moderate to high intensity (60-80% of age-predicted maximal heart rate), which will be maintained for 20 min, followed by a 5-minute cool-down. Age-predicted maximal HR will be defined as 220 beats-per-minute (BPM) minus age in years.
干预措施: Exercise (Behavioral)
结局指标
主要结局
Profile of Mood States (POMS)
时间窗: From before to immediately after a single session of exercise
POMS is a 30-item questionnaire scored on a 5-point Likert-type scale ranging from "Not at all" to "Extremely." It provides six sub≥scales: 1) anger (e.g., grouchy, furious); 2) confusion (e.g., muddled, forgetful); 3) depression (e.g., sad, unworthy); 4) fatigue (e.g., tired, sluggish); 5) tension (e.g., nervous, anxious); and 6) vigor (e.g., lively, active).
次要结局
- Subjective Exercise Experience Scale (SEES)(From before to immediately after a single session of exercise)
- Subject Happiness Scale (SHS)(From before to immediately after a single session of exercise)
- Blood biomarkers(From before to immediately after a single session of exercise)
- Cardiovascular parameters(Before, during, and immediately after a single session of exercise)
- BOLD-weighted fMRI images(From before to immediately after a single session of exercise)
- Diffusion-weighted image (DWI)(From before to immediately after a single session of exercise)
- Magnetic resonance spectroscopy (MRS)(From before to immediately after a single session of exercise)
研究者
YAU Suk Yu Sonata
Associate Professor
The Hong Kong Polytechnic University