Premeal Phosphorus Supplementation for Reducing Energy Intake and Body Weight
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 71
- 主要终点
- Body Weight
研究概览
简要总结
Phosphorus is a mineral that is naturally present in our foods and is required by our bodies for normal function. It has been found that phosphorus supplementation taken before meals has the potential to reduce meal size. However its long term effect has not been measured yet. It is well accepted that changes in body weight require about 3 months. Using body weight as the outcome, which is the ultimate outcome of weight loss approaches, would provide robust information on the role of phosphorus.
详细描述
A double-blind, randomised, placebo-controlled trial of 63 adults aged 18 to 45 years with a body mass index (BMI) of 25 kg/m2 or higher and normal kidney function at the American University of Beirut. Participants were randomly assigned to the placebo or phosphorus group where daily placebo or phosphorus supplements were ingested with three main meals (breakfast, lunch, and dinner) for a period of 12 weeks. Primary outcomes were changes in anthropometric measures, blood metabolites (including lipid profile, glucose, and insulin), and subjective appetite scores.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •CR>1mg/dl for women; Cr >1.2 mg/dl for men
- •GFR >60ml/min/1.73m2
排除标准
- •presence of any significant medical disease,
- •pregnancy or lactation,
- •regular administration of drugs that affect body weight, and
- •weight loss of 3% or more within 3 months of study entry.
结局指标
主要结局
Body Weight
时间窗: 3 months
次要结局
- Waist Circumference(3 months)
- Appetite Score on the Visual Analog Scale(6 weeks)
研究者
Omar Obeid
professor
American University of Beirut Medical Center