Efficiency of phototherapy in management of patients with allergic rhinitis

Phase 2

Conditions: Allergic Rhinitis.
Allergic rhinitis due to pollen

Registration Number: IRCT2015042621944N1

Lead Sponsor: Vice chancellor for Research, Shiraz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 64

Inclusion Criteria

Inclusion Criteria:1-Men and women 18 – 60 years of age; 2-Out-patients, with a history and diagnosis of allergic rhinitis for at least two years prior to Visit 1; 3-Allergy verified by a positive skin-prick test or specific IgE determination within two years prior to visit 1, or at visit 1; 4-Patients have allergic rhinitis with no response to previous local or systemic antihistamines/corticosteroids, or patients do not want these therapeutic measures or can 't be treated with these drugs due to side effects or any other reasons; 5-Patients having severe disease, where the global severity score was more than 6 in the 10 point scale in the last 3 days before enrollment; 6-Signed Informed Consent obtained from the patient prior to conducting any study-related procedures;

Exclusion Criteria

1-Known light-induced skin disease (photodermatosis); 2-Ongoing fungal, viral or bacterial respiratory infection; 3-Anatomic abnormalities in the nose (eg: severe septum deviation or polyps) that disturb photo therapeutically treatment, as judged by the Investigator; 4-Prohibited Medicines such as Digoxin, Doxepin, Amiodarone, Trimethoprim , Chlorpropamide, Piroxicam, Doxycycline, Promethazine all can cause photosensitivity and Wash-Out Periods for PHOTO-SENSITIZING MEDICATIONS (eg: Systemic corticosteroids: 4 weeks; Intranasal Cromolyn, Intranasal and topical corticosteroids: 2 weeks; Intranasal decongestants: 3 days; Intranasal or systemic antihistamines: 1 week; Immunotherapy: 5 years) before beginning the study; 5-Patients less than 18 years old; 6-Pregnant women; 7-Patients unable to give informed consent because of age, mental illness, dementia or communication difficulties and patients with nasopharyngeal tumors all are excluded.