Magnetic Resonance Elastography of Cardiac Transplant Rejection
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Cardiac Stiffness With Magnetic Resonance Elastography (MRE)
研究概览
简要总结
Magnetic Resonance Elastography (MRE) for cardiac transplant patients.
详细描述
Patient will undergo MRE beginning 4-8 weeks post transplant, then with each scheduled cardiac biopsy through 7-8 months post transplant. Results of the MRE will be compared against results of the cardiac biopsy to determine if the non-invasive MRE can predict cardiac transplant rejection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have undergone cardiac transplantation at the Ohio State University Ross Heart Hospital.
- •Patients must be able to lie flat on their back in the scanner for up to 60 minutes
- •Patient must be able to hold their breath for up to 15 seconds at a time.
排除标准
- •Patients who are claustrophobic
- •Patients who are pregnant, due to potential risks to the fetus.
- •Patients with any unapproved, non-MRI safe metal/devices in their bodies.
研究组 & 干预措施
Arm 1
Patients who have received a cardiac transplant at The Ohio State University Ross Heart Hospital will undergo Magnetic Resonance Elastography (MRE) (using a Magnetic Resonance Elastography driver) within 24-48 hours of standard of care biopsy. Results of both will be compared to determine if MRE can successfully predict cardiac transplant rejection.
干预措施: Magnetic Resonance Elastography driver (Device)
结局指标
主要结局
Cardiac Stiffness With Magnetic Resonance Elastography (MRE)
时间窗: 24-48 hours
MRE scans will be performed within 24-48 hours of standard of care cardiac biopsies for patients who have undergone cardiac transplant at The Ohio State University Ross Heart Hospital. Stiffness results from the MRE will be compared to histopathology from the cardiac biopsy to determine if the completely non-invasive MRE can successfully predict transplant rejection.
次要结局
未报告次要终点
研究者
Richard D. White, M.D.,
Professor and Chair, Department of Radiology
Ohio State University