CTRI/2024/02/062663已完成4 期
A randomized single-blinded placebo control study of perioperative Dexmedetomidine infusion on 24 hour morphine consumption by patient controlled analgesia(PCA) in patients undergoing major neurosurgical procedures
Saveetha Medical College1 个研究点 分布在 1 个国家目标入组 38 人开始时间: 2024年3月1日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- 24hr cumulative morphine consumption
研究概览
简要总结
Objective of the research project: To assess the post-operative opioid sparring effect of
perioperative Dexmedetomidine infusion in patients undergoing neurosurgical procedures with
post-operative Morphine consumption.
The primary objective is the comparison of cumulative morphine consumption in 24hrs
(PCA and initial titration)
Secondary objectives include comparing the time to first request for post-operative
analgesia, assessment and comparison of post-operative pain with Numerical rating
scale
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 19.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA PS 3 Elective Neurosurgical procedures.
排除标准
- •Cardiac disorders, Impaired renal, liver and pulmonary functions Intellectual disability Long term use of ACE inhibitors, Beta blockers, Sedatives, Psychiatric medications Emergency cases.
结局指标
主要结局
24hr cumulative morphine consumption
时间窗: 1hr, 2hr, 4hr, 6hr, 8hr, 12hr and 24 hr postoperative period
次要结局
- Time of First analgesic request(24 hours postoperative period)
- Post operative pain assessment using Numerical Rating Scale(1, 2,4,6,8,12,24 hrs post operative period)
- Incidence of nausea, Vomiting(24 hours postoperative period)
研究者
Bharat Krishna
Saveetha Medical College
研究点 (1)
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