Antibacterial Properties of Silicon Incorporated With Quaternary Ammonium Polyethylenimine Nanoparticles
Phase 1
- Conditions
- Carcinoma of Head and Neck
- Registration Number
- NCT01007240
- Lead Sponsor
- Hadassah Medical Organization
- Brief Summary
The aim of this study is to evaluate the antibacterial activity of crosslinked quaternary ammonium polyethylenimine (PEI) nanoparticles incorporated at 1-2% w/w in a commercial soft liner material when compared to the commercial soft liner material.
The investigators' results in vitro showed a significant delay in bacterial growth.
Therefore, the investigators assume to have the same delay in vivo- on patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- patients post maxillectomy, who are using obturators
Exclusion Criteria
- patients who are not using obturators
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method bacterial growth a week
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What is the molecular mechanism of antibacterial activity in quaternary ammonium PEI nanoparticles (NCT01007240) for head and neck carcinoma obturators?
How does the antibacterial efficacy of 1-2% w/w quaternary ammonium PEI nanoparticles compare to standard commercial soft liners in vivo for head and neck cancer obturators?
Are there specific biomarkers that predict enhanced antibacterial response to quaternary ammonium PEI nanoparticle incorporation in silicone obturators for head and neck carcinoma patients?
What are the potential adverse events associated with quaternary ammonium PEI nanoparticle incorporation in silicone obturators for head and neck carcinoma patients, and how are they managed?
What other antimicrobial agents are combined with silicone in obturators for head and neck carcinoma, and how do they compare to quaternary ammonium PEI nanoparticles in clinical settings?