Effect of Goal-directed Fluid Therapy Based on Stroke Volume Variation on Metabolic Acidosis in Patients Undergoing Brain Tumor Surgery

Not Applicable

Completed

• Conditions: Brain Tumor
• Interventions: Drug: CVP; Drug: SVV

• Registration Number: NCT01738880
• Lead Sponsor: Yonsei University

Brief Summary

In patients undergoing craniotomy, 0.9% normal saline is commonly administered in order to reduce cerebral edema. Excessive administration of 0.9% normal saline has been to reported to cause hyperchloremic metabolic acidosis. On the other hand, hypovolemia due to insufficient fluid replacement for perioperative loss can also result in metabolic acidosis by lactic acid accumulation. However, the guideline for perioperative fluid management has not been yet established. The investigators hypothesized that intraoperative fluid management according to SVV(Stroke Volume Variation)could reduce perioperative metabolic acidosis compared to those by CVP(Central Venous Pressure). Therefore, the study is trying to determine if intraoperative fluid administration based on SVV could reduce metabolic acidosis when compared with CVP in patients undergoing craniotomy due to brain tumor who receive 0.9% normal saline as main fluid regimen.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2012-11-18
• Study First Submitted QC: 2012-11-27
• Study First Posted: 2012-11-30
• Study Start: 2012-12
• Primary Completion: 2014-06
• Study Completion: 2014-07
• Status Verified: 2015-01
• Last Update Submitted: 2015-01-26
• Last Update Posted: 2015-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients undergoing craniotomy due to brain tumor
• American Society of Anesthesiologists physical status I or II
• aged from 20 to 65

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Exclusion Criteria

• compromised cardiopulmonary function
• diabetes mellitus
• symptom or sign with increased intracranial pressure
• liver or renal disease
• pre-existing metabolic acidosis
• pregnant or breast-feeding
• patients who cannot understand the statements for subjects

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group C	CVP	intraoperative fluid management based on CVP
group S	SVV	intraoperative fluid management based on SVV

Primary Outcome Measures

Name	Time	Method
Standard base excess point	at the suturing of scalp

Trial Locations

Locations (1)

Severance hospital; 🇰🇷 Seoul, Korea, Republic of