Histologic Response to UVA and UVB Exposure During the Use of Sunscreen

Not Applicable

Completed

• Conditions: Solar Elastosis

• Registration Number: NCT01892150
• Lead Sponsor: Mahidol University

Brief Summary

Anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

Detailed Description

Premature aging can be prevented by using sunscreen. Currently, anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-05-23
• Study First Submitted QC: 2013-06-30
• Primary Completion: 2013-07
• Study Completion: 2013-07
• Study First Posted: 2013-07-04
• Status Verified: 2014-03
• Last Update Submitted: 2014-03-27
• Last Update Posted: 2014-03-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 2

Inclusion Criteria

• subjects aged 35-65 years who were scheduled for abdominoplasty
• the excised area should be larger than 18x10 cm2
• no skin diseases or lesions on the excised area
• no topical treatment on excised area more than 1 month prior to this study

Exclusion Criteria

• pregnancy
• lactation
• have tattoo or striae distensae on abdomen

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
H&E Staining	2 Months	Review difference in H\&E staining in tissue biopsy before and after UVA / UVB irradiation

Secondary Outcome Measures

Name	Time	Method
Tyrosinase Staining	2 Months	Review difference in Tyrosinase staining in tissue biopsy before and after UVA / UVB irradiation to evaluate the effects of pigment darkening after UV exposure

Trial Locations

Locations (1)

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University; 🇹🇭 Bangkok, Thailand