Effect of Intake of Citron(Citrus Junos Siebold ex Tanaka) Peel Extract on Blood Cholesterol.

Not Applicable

Completed

• Conditions: Hyperlipidemia
• Interventions: Dietary Supplement: Citron peel extract; Dietary Supplement: Placebo

• Registration Number: NCT03332641
• Lead Sponsor: Hanyang University

Brief Summary

This study was conducted to investigate the effects of daily supplementation of Citron(Citrus Junos Siebold ex Tanaka) Peel Extract on improvement of Blood Cholesterol.

Detailed Description

This study was a 12 weeks, randomized, double-blind, placebo-controlled human trial. Twenty subjects were randomly divided into Citron(Citrus Junos Siebold ex Tanaka) Peel Extract or a placebo group. Blood cholesterol profiles before and after the intervention.

Study Timeline

• Study Start: 2017-06-07
• Primary Completion: 2017-09-28
• Study Completion: 2017-09-28
• Status Verified: 2017-11
• Study First Submitted: 2017-11-02
• Study First Submitted QC: 2017-11-02
• Study First Posted: 2017-11-06
• Last Update Submitted: 2017-11-16
• Last Update Posted: 2017-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Age 19-75 years with Total cholesterol 200-239 mg/dL

Exclusion Criteria

• Lipid lowering agent within past 6 months
• Severe cardiovascular disease(Mvodardial infarction, stroke, etc)
• Renal disease(Heredity hyperlipidemia, Acute/Chronic renal failure, Nephrotic syndrome, ect)
• Cancer, Respiratory organ disease(Asthma, Chronic obstructive pulmonary disease)
• Diabetes mellitus
• Allergic or hypersensitive to any of the ingredients in the test products
• History of disease that could interfere with the test products or impede their absorption
• Under antipsychotic drugs therapy within past 2 months
• History of alcohol or substance abuse
• Participation in any other clinical trials within past 2 months
• Laboratory test by show the following results
• Pregnancy or breast feeding
• Not Contraception(except: Surgery for female infertility)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Citron peel Extract	Citron peel extract	Citron peel extract for 12 weeks
Placebo	Placebo	Placebo for 12 weeks

Primary Outcome Measures

Name	Time	Method
Changes of Cholesterol	12 weeks	Changes of Cholesterol were assessed before and after the intervention

Secondary Outcome Measures

Name	Time	Method
Changes of Lipid profile	12 weeks	Changes of Lipid profile were assessed before and after the intervention
Changes of Oxidized LDL	12 weeks	Changes of Oxidized LDL were assessed before and after the intervention

Trial Locations

Locations (1)

Hanyang University; 🇰🇷 Seoul, Korea, Republic of