NCT01415973已完成不适用
Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- skeletal muscle synthetic and breakdown rate
研究概览
简要总结
This study will compare the effects of cooked, ground beef to those of beef protein isolate on blood and muscle proteins.
详细描述
STUDY OBJECTIVES Primary: To compare the effects of consumption of a 3-ounce serving of beef to that of a 20g serving of BPI on skeletal muscle synthetic and breakdown rate in healthy elderly subjects.
Secondary: To investigate the effect the study products on plasma levels of amino acids, insulin, and glucose in healthy elderly subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male or female.
- •Age 60 years or older.
排除标准
- •Any (history of) gastrointestinal disease that interferes with GI function
- •Diagnosed and active treatment of Diabetes Mellitus type I or II
- •History of congestive heart failure
- •Recent (6 months) hospitalization for heart disease treatment or management (e.g. PTCA, stent, surgery)
- •Myocardial infarction in the past year
- •Infection or fever in the 7 days prior to enrollment
- •Current use of corticosteroids, growth hormone, or testosterone
- •Adherence to a weight loss diet
- •Use of protein-containing or amino acid-containing nutritional supplements within one week of enrollment
- •Current alcohol (>7 ETOH per week) or drug abuse
- •Platelet count (PLT) < 100,000
- •History of hypo- or hyper-coagulation disorders including use of a coumadin derivative
- •Currently taking anti-thrombotics and cannot stop for 7 days (i.e. medical indication)
- •Allergy to local anesthetic
- •Blood hemoglobin < 9.0 g/dL
- •Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements
结局指标
主要结局
skeletal muscle synthetic and breakdown rate
时间窗: day one
Using stable isotope infusion/ingestion methodology, we will measure plasma and skeletal muscle metabolic rate. Our primary end points will be muscle protein fractional synthesis rate (FSR) and whole body protein turnover rate.
次要结局
- concentrations of plasma amino acids, insulin and glucose(day one)
研究者
研究点 (2)
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