Effect of Amlodipine on reduce of iron overload in patiens with thalassemia
Phase 2
- Conditions
- major thalassemia.Major thalassemia
- Registration Number
- IRCT2015080720715N2
- Lead Sponsor
- Vice Chancellor for research of Arak University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patients with major thalassemia ?? ?with ?regular blood transfusions; using iron chelating agents ?regularly; age above 7 years old.?
Exclusion criteria: Patients who changed their chelating ?agents during the last 6 months; renal and hepatic ?failure; cardiac output less than 35%; systolic blood ?pressure less than 90 millimeter Hg, patients with HIV ?and hepatitis B and C.?
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ferritin Levels. Timepoint: Beginning and 1 and 6 and 12 months after treatment. Method of measurement: blood test.;Tissue iron level. Timepoint: Beginning, 6 months, 12months after treatment. Method of measurement: T2*MRI.
- Secondary Outcome Measures
Name Time Method Blood pressure. Timepoint: Monthly. Method of measurement: Barometer.