Effects of N-acetylcysteine on Pulmonary Function in High-risk Patients Undergoing Off-pump Coronary Bypass Surgery
Phase 4
Completed
- Conditions
- Coronary Artery Occlusion
- Interventions
- Drug: N-acetylcysteine, saline
- Registration Number
- NCT01021163
- Lead Sponsor
- Yonsei University
- Brief Summary
The purpose of this study is to study the effects of N-acetylcysteine on pulmonary function in high-risk patients undergoing off-pump coronary bypass surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
- Adult patients with Euroscore ≥ 5
Exclusion Criteria
- Patients in need of emergency surgery,acute renal failure patients, kidney transplanted patients, patients injected with NAC 5days before planned surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description N-acetylcysteine , saline N-acetylcysteine, saline -
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms of N-acetylcysteine improve pulmonary function in off-pump coronary bypass surgery patients with coronary artery occlusion?
How does N-acetylcysteine compare to corticosteroids in reducing postoperative pulmonary complications in high-risk coronary artery occlusion patients?
Which biomarkers correlate with N-acetylcysteine efficacy in NCT01021163 for off-pump coronary bypass surgery outcomes?
What adverse events are reported with N-acetylcysteine in off-pump coronary bypass surgery and how are they managed in high-risk populations?
Are there combination therapies involving N-acetylcysteine and glutathione precursors that enhance pulmonary protection during off-pump coronary artery bypass grafting?
Trial Locations
- Locations (1)
Severance Hospital
🇰🇷Seoul, Korea, Republic of