Identification of Genetic Factors Determining Disease Course in the New Type of Coronavirus Infection, COVID-19

• Conditions: COVID-19; Sars-CoV2

• Registration Number: NCT04426253
• Lead Sponsor: Szeged University

Brief Summary

The study aims to identify environmental factors and genetic (gene mutation and gene expression) changes, which influencing the course of the disease the new type of coronavirus infection COVID-19 in patients nationwide in a multicenter study.

At first in the study will be performed 200 patients, selected for a homogeneous groups on the basis of the patient's anamnestic data, genetic testing.

Following the interim analysis, based on the results, another 800 people are planned to involve.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-06
• Study Start: 2020-06-05
• Study First Submitted: 2020-06-09
• Study First Submitted QC: 2020-06-09
• Last Update Submitted: 2020-06-09
• Study First Posted: 2020-06-11
• Last Update Posted: 2020-06-11
• Primary Completion: 2020-12-31
• Study Completion: 2021-07-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• confirmed covid 19 infection

Exclusion Criteria

• informed refusal

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identification of genetic factors determining the course of the disease in case of COVID-19	2020. December	Exploring genotype-phenotype connections based on anamnestic data of patients and joint bioinformatics analysis of its genetic variants

Trial Locations

Locations (14)

University of Pécs 1st Department of Internal Medicine Intensive Care Unit; 🇭🇺 Pécs, Hungary

University of Pécs First Department of Internal Medicine; 🇭🇺 Pécs, Hungary

University of Pécs Szentágothai Research Centre Genomics and Bioinformatics Core Facility; 🇭🇺 Pécs, Hungary

University of Szeged Department of Medical Biology; 🇭🇺 Szeged, Hungary

University of Pécs Infection Department of the Coronavirus Center; 🇭🇺 Pécs, Hungary

University of Szeged Institute of Medical Microbiology and Immunobiology; 🇭🇺 Szeged, Hungary

University of Pécs Institute of Laboratory Medicine; 🇭🇺 Pécs, Hungary

University of Pécs Szentágotahi Research Centre; 🇭🇺 Pécs, Hungary

University of Szeged Department of Anaesthesiology And Inthensive Therapy; 🇭🇺 Szeged, Hungary

University of Szeged Department of Dermatology and Allergology; 🇭🇺 Szeged, Hungary

University of Szeged First Department of Medicine; 🇭🇺 Szeged, Hungary

University of Szeged Szentágothai Research Centre Virology Research Group; 🇭🇺 Pécs, Hungary

University of Szeged Institute of Clinical Microbiology; 🇭🇺 Szeged, Hungary

University of Szeged Department of Paediatrics; 🇭🇺 Szeged, Hungary