The Effect of Tranexamic Acid on Postoperative Blood Loss and Coagulation in Patients With Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft; Double Blind Randomized Control Study

Phase 4

Completed

• Conditions: Coronary Artery Occlusive Disease
• Interventions: Drug: Tranexamic Acid

• Registration Number: NCT01067638
• Lead Sponsor: Yonsei University

Brief Summary

The Effect of Tranexamic Acid on Postoperative Blood loss and Coagulation in Patients with Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft; double blind randomized control study.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-11
• Study First Submitted: 2010-01-15
• Study First Submitted QC: 2010-02-10
• Study First Posted: 2010-02-11
• Primary Completion: 2010-09
• Study Completion: 2010-09
• Status Verified: 2010-12
• Last Update Submitted: 2010-12-03
• Last Update Posted: 2010-12-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Fifty patients undergoing OPCAB with preoperative hematocrit levels lower than 35%

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Exclusion Criteria

Patient who has

• Open heart surgery history before
• Thrombosis history
• Myocardial infarction (MI) within 7days recently
• Liver or Kidney disease
• been scheduled emergency surgery

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
tranexamic acid	Tranexamic Acid	Tranexamic Acid on Postoperative Blood loss and Coagulation in Patients with Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft

Primary Outcome Measures

Name	Time	Method
Tranexamic acid significantly reduce the amount and incidence of homologous transfusion in anemic patients undergoing off-pump coronary artery bypass (OPCAB)	Check the amount 3 times before sugery and 24 hours after surgery

Trial Locations

Locations (1)

Yonsei Univ.; 🇰🇷 Seoul, Korea, Republic of