Lung Ultrasound Guided Fluid Management Protocol for the Critically Ill Patient: a Randomized Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- 28 days survival
研究概览
简要总结
In the Intensive Care Unit (ICU) this bedside method of assessing lung congestion could be useful in a better management of the critically ill patients with a wide range of respiratory failure causes (Acute Respiratory Distress Syndrome, COPD, acute pulmonary edema, pneumonia etc.). Fluid management is a key issue in the ICU where patients are either hemodynamic unstable and/or mechanically ventilated. A randomized study is proposed where in the interventional arm the fluid management (volume replacement, diuretics, use of vasopressors) will be guided using the BLS as a sign of pulmonary congestion.
详细描述
Inclusion criteria
- Age 18 or older admitted to the Intensive Care Unit
Exclusion criteria
- Due to LUS measurement limitation: patients with known persistent pleurisy, pulmonary fibrosis or pneumectomy;
- Unwillingness to participate in the study.
Active arm diuretic administration algorithm
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Results of the lung ultrasounds will not be made publicly available
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 or older admitted to the Intensive Care Unit
排除标准
- •known persistent pleurisy, pulmonary fibrosis or pneumectomy (due to lung ultrasonography limitations);
- •unwillingness to participate in the study
研究组 & 干预措施
intervention group pulmonary congestion
in the intervention group pulmonary congestion, as assessed by the BLS will guide the diuretic and fluid management, with a target of below 15 BLS. Furthermore, in the active arm, in the patients who will require a renal replacement therapy (RRT), BLS will be used to further guide the dialysis fluid prescription.
干预措施: Fluid management guided by BLS (Other)
Control group
control group the fluid management will not be LUS guided
结局指标
主要结局
28 days survival
时间窗: 28 days
all-cause mortality
次要结局
- Intensive care unit hospitalization(28 days)
- Duration of hospitalization(28 days)
- Days on mechanical ventilation(28 days)
研究者
Professor Adrian Covic
Clinical Professor
Grigore T. Popa University of Medicine and Pharmacy