Evaluation of Microbial Composition in Human Milk From Healthy Women in the Turkish Population: an Observational Cross-sectional Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Microbial Community in Breast Milk
- Sponsor
- Hacettepe University
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Microbial abundance and diversity
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Breast milk is an optimal source of nutrients for newborns as well as a potential source of bacteria for the intestinal microbiota. However, there are limited number of studies evaluating the relationship between maternal nutrition, breast milk and neonatal intestinal microbiota.
Detailed Description
The study was conducted on a total of 20 healthy women following at Obstetrics and Gynecology Department of Gülhane Education and Research Hospital in Ankara Health Sciences University. Sociodemographic characteristics, anthropometric measurements, breastfeeding characteristics were evaluated in the third trimester of the women who underwent routine prenatal care. Breast milk samples were obtained at 16.day postpartum during lactation.
Investigators
F. Gülhan Samur
Prof. Dr.
Hacettepe University
Eligibility Criteria
Inclusion Criteria
- •Singleton pregnancy
- •Age 19-35 years
- •At weeks of 30-36 gestation
- •No history of acute or chronic diseases
- •Term delivery
Exclusion Criteria
- •Alcohol use
- •Gestational diabetes
- •Type 1 and 2 diabetes
- •Preeclampsia
- •Polycystic ovary
- •Thyroid and parathyroid disease
- •Metabolic bone or kidney disease
- •Abnormal liver function
- •Multiple pregnancy
- •Premature and postmature labor
Outcomes
Primary Outcomes
Microbial abundance and diversity
Time Frame: at 16 day postpartum
The microbial composition of the breast milk samples was determined by 16S rRNA (ribosomal ribonucleic acid) gene sequencing analysis.