Eptinezumab as an Adjunct to Standard of Care for MIGRANE in an Acute EmeRgency Context (Migraine ERase Study)
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Migraine
- Sponsor
- Dr George Medvedev
- Enrollment
- 102
- Locations
- 2
- Primary Endpoint
- Number of migraine days at week 1
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
The purpose of the study is to investigate how a medication called eptinezumab (Vyepti) given to patients in the Emergency Department (ED) might help prevent migraines from happening again. The results of this study may help inform better ways to manage patients with migraines in the ED.
Eptinezumab is currently approved by Health Canada for the preventive treatment of migraine, but its short-term effectiveness in the ED context is unknown. Unlike other migraine treatments used in the ED, eptinezumab can rapidly interrupt the migraine process, potentially also preventing migraine from coming back in the short term.
Most patients with a diagnosis of migraine have no access to preventative therapies. This study will be able to provide access to preventative therapy at the earliest stages of a migraine attack. Administering this medication in the ED may stop the attack more effectively compared to current therapies.
This study wants to see if eptinezumab could help stop migraines from coming back after individuals have been treated in the ED. The study will also explore whether eptinezumab could reduce how often individuals with migraine might need to come back to the ED, what other medications they might need alongside eptinezumab, and how they feel overall.
Investigators
Dr George Medvedev
Principal Investigator
HealthTech Connex Inc.
Eligibility Criteria
Inclusion Criteria
- •Adults between the ages of 19-75 with a history of migraines, as established at the time of presentation to the ED or known from the patient's chart;
- •Presenting to the emergency department with a migraine that meets ICHD-3 migraine headache criteria;
- •Provided signed informed consent;
- •Sufficient literacy and cognitive capacity to understand and complete patient self-rated questionnaires in English.
Exclusion Criteria
- •Secondary headaches caused by an injury or underlying illness, such as a concussion, bleeding in the brain, an infection or a brain tumor
- •Current or history of severe cardiovascular disease or renal dysfunction
- •A systemic condition in the stage of active treatment (vasculitis, etc.)
- •Pregnant or at risk of becoming pregnant (absent contraception)
- •Currently enrolled in another investigational drug trial
- •Dosed with eptinezumab within the past 3 months
- •Currently on anti-CGRP therapy with monoclonal antibodies
- •Currently involved in active litigation
- •Any other condition which, in the opinion of the Investigator, would exclude the participant due to reasons of safety or data integrity
- •Hypersensitivity to the active substance or to any of the excipients
Outcomes
Primary Outcomes
Number of migraine days at week 1
Time Frame: Baseline to Week 1
Number of migraine days at week 1, as reported in daily Headache Diary
Secondary Outcomes
- Number of monthly headache days(Baseline to Month 3)
- Generalized Anxiety Disorder 7-item (GAD-7)(Baseline to Month 3)
- Patient Health Questionnaire (PHQ-9)(Baseline to Month 3)
- Readmission to the Emergency Department (ED)(Baseline to Month 3)
- Migraine recurrence(Baseline to Month 3)
- Sleep Quality(Baseline to Month 3)
- Headache Impact Test (HIT-6)(Baseline to Month 3)
- Patient Global Impression of Change (PGI-C)(Baseline to Month 3)
- Work Productivity and Activity Impairment (WPAI)(Baseline to Month 3)