ocebo effects on pressure pai
Completed
- Conditions
- The study is conducted in a sample of healthy volunteers.
- Registration Number
- NL-OMON23815
- Lead Sponsor
- eiden University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 124
Inclusion Criteria
Healthy female volunteers between 18 and 35 years old, with a good understanding of written and spoken Dutch.
Exclusion Criteria
Severe somatic or psychiatric morbidity (e.g., heart/lung diseases, DSM-V psychiatric disorders), Raynaud’s disease, chronic pain complaints at present or in the past, current pain complaints, current use of medication, injuries on the non-dominant hand, refusal/inability to remove nail polish or artificial nails for the experiment, pregnancy, color-blindness.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The change in nocebo effect from after nocebo conditioning (part 1) to after counterconditioning, extinction, and continued nocebo conditioning (part 2) will be compared across groups. Nocebo effects will be calculated by taking the mean difference of pain ratings during experimental trials (placebo TENS device activation) versus pain ratings during control trials (placebo TENS device deactivation) in the test phase.
- Secondary Outcome Measures
Name Time Method The comparison of the induction of nocebo effects after nocebo conditioning and sham conditioning. The mean difference between self-reported pain ratings during experimental and control trials of the testing phase (i.e., nocebo effects) will be calculated for nocebo conditioning and sham conditioning groups, and then compared.