Cardiovascular Impact, Quality e Quantity of Sleep in Bed Partners of Patients With Obstructive Sleep Apnea: a Randomized Study
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Sleep Apnea Syndromes
- Sponsor
- University of Sao Paulo
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Endothelial function (forearm dilation, FMD - %)
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
Obstructive sleep apnea (OSA) is a common clinical condition associate with a negative impact not limited to the patients but also to the partner that sleep in the same bed. Is it reasonable to speculate that the partner suffer sleep deprivation, increased level of irritability, insomnia, fatigue, among others due to the loud snoring caused by the OSA patient. Although previous data reported impaired sleep quality in partners of patients with OSA, it is not clear in literature whether OSA promotes cardiovascular impact and if the treatment of OSA promotes some cardiovascular benefits in (the) partner beyond the improvements in the subjective and objective sleep. Thus, the main objectives of this randomized controlled study are: to evaluate the impact of three months of randomization (treatment with nasal CPAP or nasal strips) on the endothelial function, blood pressure (ambulatory blood pressure monitoring), sleep duration (wrist actigraphy for 1 week) and sleep quality (Pittsburgh Questionnaire) and the frequency of OSA in the bed partners of patients with moderate to severe OSA.
Investigators
Luciano F Drager, MD, PhD
Associate Professor of Medicine
University of Sao Paulo
Eligibility Criteria
Inclusion Criteria
- •Bed partners of patients with moderate to severe OSA
Exclusion Criteria
- •Bed partners with OSA using specific treatment.
Outcomes
Primary Outcomes
Endothelial function (forearm dilation, FMD - %)
Time Frame: 3 months
Secondary Outcomes
- Frequency of OSA(Baseline only)
- Ambulatory blood pressure monitoring (ABPM)(3 months)
- Sleep quantity (measured by actigraphy - hours/night)(3 months)
- Sleep quality (Pittsburgh Questionnaire)(3 months)