Effects of COX 1-2 Inhibitors on Prevention of Rocuronium Injection Pain: Controlled, Randomised, Double Blind Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- The injection pain due to rocuronium
研究概览
简要总结
Purpose : The aim of the study is to investigate the effects of cox inhibitors as a rescue agent against the rocuronium pain Methodology : Sixty patients enrolled for the general anesthesia enrolled in this study. Patients were allocated into two groups (Group 1: Dexketoprofen group, Group 2: Control group) .Pain was evaluated by during rocuronium injection, patients were scored by a scale showed below.
0;No movement response to injection
- Mild movement response to injection
- Hand withdrawal response to injection
- Arm withdrawal response to injection Investigators also evaluated the pain with 2 questions when the patient was in the recovery room.
Question 1.What was the last feeling before participants fall into sleep? question 2. Did participants feel any pain on participants's hand during medication injection for anesthesia?
详细描述
Purpose : Rocuronium bromide is a painful agent while general anesthesia induction. The aim of the study is to investigate the effects of cox inhibitors as a rescue agent against the rocuronium pain Methodology : Sixty patients enrolled for the general anesthesia enrolled in this study. Patients were allocated into two groups (Group 1: Dexketoprofen group, Group 2: Control group) .Pain was evaluated by during rocuronium injection, patients were scored by a scale showed below.
0;No movement response to injection
- Mild movement response to injection
- Hand withdrawal response to injection
- Arm withdrawal response to injection Investigators also evaluated the pain with 2 questions when the patient was in the recovery room.
Question 1.What was the last feeling before participants fall into sleep? question 2. Did participants feel any pain on participants's hand during medication injection for anesthesia?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non allergic to dexketoprofen
- •18-60 years old
- •American Society of Anesthesiologists(ASA) 1-2-3
- •70-90 kg weigh
排除标准
- •patients with psychiatric and mental problems
研究组 & 干预措施
Dexketoprofen group,
IV cannulation was performed on hand dorsum or brachial and canulation place was recorded. Patients allocated in dexketoprofen group were administered intravenous dexketoprofen (50 mg/2ml) and 0,3 mg/kg midazolam 10 minutes prior to general anesthesia induction
干预措施: Dexketoprofen (KETAVEL 50 mg/2 ml) (Drug)
Saline group
IV cannulation was performed on hand dorsum or brachial and canulation place was recorded. Patients allocated in control group were administered intravenous 2 ml of saline and 0,3 mg/kg midazolam 10 minutes prior to general anesthesia induction
干预措施: Saline (Isotonic Saline Solution 0.9% ) (Drug)
结局指标
主要结局
The injection pain due to rocuronium
时间窗: 1 month
Pain will be recorded and graded using a 4-point scale (none, mild, moderate, or severe).
次要结局
- Score on pain due to injection of rocuronium(1 month)
研究者
Mehmet sahap
Assistant professor
Ankara City Hospital Bilkent