Research on the Effect and Mechanism of Aerobic Exercise on Parkinson's
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Montreal Cognitive Assessing(MoCA) score
研究概览
简要总结
This trial is expected to recruit patients with primary Parkinson's disease and give them four consecutive weeks of aerobic exercise to observe its effect on Parkinson's disease and explore its mechanism
详细描述
This trial is expected to recruit patients with primary Parkinson's disease who are distributed into tremor group and stiff group and give them the same kind of four consecutive weeks of aerobic exercise to observe its effect on Parkinson's disease and explore its mechanism
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants were diagnosed primary PD according to the 2015 MDS diagnostic criteria
- •Participants are between 55 and 65 years old
排除标准
- •Severe heart
- •liver dysfunction
- •kidney dysfunction
- •severe cognitive dysfunction
- •severe anxiety and depression
- •history of mental illness
- •history of cerebral infarction or ischemic attack in the past three months
- •acute myocardial infarction or acute coronary in the past three months
- •Parkinson's Pulse syndrome
- •medication history (drugs that improve blood circulation in the brain and increase the excitability of the nervous system)
结局指标
主要结局
Montreal Cognitive Assessing(MoCA) score
时间窗: changes of MoCA score from baseline at four weeks
to assess the cognitive function of PD,0-30 scores,the higher scores mean better function
Non-Motor Symptom Scale (NMSS)
时间窗: changes of NMSS score from baseline at four weeks
to assess the non-motor of PD , 0-120 scores, the higher scores mean severe non-motor damage
The Epworth Sleeping Scale(ESS)
时间窗: changes of ESS score from baseline at four weeks
to assess the degree of drowsiness, 0-24 scores, the higher scores mean severe drowsiness
Movement Disorder Society-United Parkinson's Disease Rating Scale (MDS-UPDRS)
时间窗: changes of MDS-UPDRS score from baseline at four weeks
to assess the motor and nonmotor function of PD,0-200 scores,the higher scores mean lower function
次要结局
- the level of arterial blood pressure(changes of the arterial blood pressure from baseline at four weeks)
- the concentration of microRNA in peripheral blood by gene chip(changes of microRNA from baseline at four weeks)
- cerebral blood variation by Head MRI(changes of the cerebral blood from baseline at four weeks)
- cerebral blood flow velocity(changes of the cerebral blood flow velocity from baseline at four weeks)
研究者
Zhang Ying
Professor
The First Hospital of Jilin University